| SP | Walsh, E.Walsh, Ed † $ >> | 29 | 1910 | R | 93 | 35 | 35 | 20 | 10 | 2.66 | .262 | 1.06 | 7.0 | 2.5 | 4.7 | 281.1 | 220 | 97 | 83 | 17 | 77 | 148 | 13 | 0 | 0 | 2 | 26 | 3 | 1 | 3.59 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 34 | 34 | 22 | 5 | 3.58 | .287 | 1.17 | 8.5 | 2.1 | 4.6 | 244.0 | 230 | 101 | 97 | 27 | 56 | 125 | 3 | 0 | 0 | 2 | 18 | 8 | 3 | 4.20 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 61 | 33 | 33 | 18 | 8 | 3.72 | .313 | 1.35 | 7.5 | 4.6 | 3.8 | 225.0 | 188 | 105 | 93 | 14 | 116 | 94 | 2 | 0 | 0 | 1 | 21 | 4 | 6 | 4.57 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 78 | 0 | 7 | 2 | 2.23 | .253 | 1.01 | 6.0 | 3.2 | 7.9 | 96.2 | 64 | 24 | 24 | 13 | 34 | 84 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 4.07 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 50 | 0 | 4 | 0 | 2.51 | .255 | 1.01 | 5.8 | 3.3 | 9.9 | 57.1 | 37 | 16 | 16 | 3 | 21 | 63 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 2.63 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 28 | 0 | 4 | 3 | 2.06 | .258 | 1.04 | 5.8 | 3.7 | 8.3 | 39.1 | 25 | 9 | 9 | 2 | 16 | 36 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.05 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 20 | 0 | 5 | 1 | 2.42 | .256 | 1.03 | 7.8 | 1.6 | 8.2 | 22.1 | 19 | 6 | 6 | 3 | 4 | 20 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 3.50 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 68 | 0 | 1 | 1 | 3.54 | .280 | 1.16 | 6.0 | 4.4 | 9.1 | 61.0 | 41 | 25 | 24 | 2 | 30 | 62 | 0 | 56 | 9 | 0 | 0 | 0 | 6 | 2.87 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 27 | 25 | 11 | 9 | 5.52 | .310 | 1.33 | 8.1 | 3.8 | 7.5 | 150.0 | 135 | 98 | 92 | 20 | 64 | 125 | 1 | 0 | 0 | 0 | 10 | 3 | 1 | 4.41 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 21 | 0 | 1 | 0 | 4.73 | .360 | 1.65 | 9.3 | 5.9 | 5.2 | 26.2 | 27 | 14 | 14 | 2 | 17 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.92 |