| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 25 | 18 | 7 | 11 | 4.70 | .319 | 1.38 | 9.3 | 3.2 | 4.0 | 141.2 | 145 | 83 | 74 | 15 | 50 | 62 | 2 | 0 | 0 | 0 | 7 | 4 | 3 | 4.65 |
| SP | Maddux, G.Maddux, Greg # $ >> | 29 | 1995 | R | 89 | 31 | 31 | 11 | 11 | 4.35 | .291 | 1.21 | 9.1 | 1.8 | 5.7 | 223.1 | 226 | 116 | 108 | 26 | 44 | 140 | 2 | 0 | 0 | 0 | 16 | 5 | 6 | 3.92 |
| SP | Arrieta, J.Arrieta, Jake # $ >> | 29 | 2015 | R | 93 | 30 | 30 | 12 | 12 | 4.07 | .303 | 1.29 | 8.4 | 3.2 | 8.4 | 208.0 | 194 | 108 | 94 | 20 | 74 | 194 | 2 | 0 | 0 | 1 | 19 | 3 | 5 | 3.50 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 30 | 30 | 14 | 10 | 4.64 | .331 | 1.47 | 9.4 | 3.9 | 5.1 | 194.0 | 202 | 108 | 100 | 16 | 83 | 110 | 3 | 0 | 0 | 2 | 17 | 3 | 2 | 4.27 |
| SP | Snell, B.Snell, Blake # $$ >> | 25 | 2018 | L | 80 | 29 | 28 | 14 | 3 | 4.63 | .317 | 1.35 | 8.3 | 3.9 | 9.1 | 161.1 | 148 | 87 | 83 | 19 | 70 | 163 | 0 | 0 | 0 | 0 | 13 | 7 | 16 | 3.94 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 51 | 0 | 4 | 3 | 4.50 | .333 | 1.46 | 7.8 | 5.3 | 10.0 | 46.0 | 40 | 23 | 23 | 8 | 27 | 51 | 0 | 3 | 0 | 0 | 0 | 2 | 6 | 4.93 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 40 | 0 | 1 | 1 | 4.82 | .341 | 1.55 | 8.8 | 5.4 | 8.5 | 37.1 | 36 | 27 | 20 | 3 | 22 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 28 | 0 | 0 | 2 | 4.35 | .374 | 1.79 | 11.7 | 5.0 | 7.7 | 20.2 | 26 | 17 | 10 | 3 | 11 | 17 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.90 |
| CL | Gagne, E.Gagne, Eric † $$ >> | 27 | 2003 | R | 98 | 57 | 0 | 2 | 5 | 3.86 | .268 | 1.08 | 6.7 | 3.1 | 9.8 | 58.1 | 43 | 25 | 25 | 4 | 20 | 63 | 0 | 35 | 5 | 0 | 0 | 1 | 2 | 2.81 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 24 | 15 | 9 | 6 | 6.11 | .350 | 1.60 | 10.3 | 4.1 | 5.7 | 131.0 | 150 | 97 | 89 | 25 | 60 | 83 | 1 | 0 | 0 | 0 | 6 | 2 | 2 | 5.63 |