| SP | Koufax, S.Koufax, Sandy $$ >> | 30 | 1965 | L | 97 | 16 | 16 | 8 | 4 | 4.34 | .301 | 1.25 | 8.9 | 2.3 | 7.5 | 114.0 | 113 | 60 | 55 | 19 | 29 | 95 | 2 | 0 | 0 | 0 | 9 | 5 | 0 | 4.39 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 16 | 16 | 6 | 3 | 4.33 | .300 | 1.28 | 8.5 | 3.0 | 8.0 | 95.2 | 90 | 47 | 46 | 15 | 32 | 84 | 0 | 0 | 0 | 0 | 7 | 1 | 2 | 4.33 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 16 | 16 | 7 | 6 | 5.74 | .333 | 1.49 | 11.8 | 1.6 | 5.0 | 102.0 | 134 | 74 | 65 | 14 | 18 | 57 | 1 | 0 | 0 | 0 | 5 | 1 | 3 | 4.23 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 15 | 15 | 3 | 7 | 5.33 | .347 | 1.55 | 9.7 | 4.2 | 4.9 | 98.0 | 106 | 67 | 58 | 10 | 46 | 53 | 2 | 0 | 0 | 0 | 6 | 4 | 3 | 4.78 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 52 | 43 | 0 | 2 | 1 | 3.27 | .298 | 1.25 | 8.8 | 2.5 | 8.4 | 44.0 | 43 | 17 | 16 | 4 | 12 | 41 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.20 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 39 | 0 | 0 | 1 | 2.82 | .256 | 1.03 | 7.2 | 2.3 | 9.2 | 44.2 | 35 | 14 | 14 | 2 | 11 | 45 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 2.30 |
| CL | Hader, J.Hader, Josh $ >> | 24 | 2018 | L | 93 | 40 | 0 | 3 | 6 | 3.43 | .360 | 1.64 | 7.3 | 7.5 | 9.2 | 42.0 | 34 | 25 | 16 | 6 | 35 | 43 | 0 | 20 | 4 | 0 | 0 | 2 | 0 | 5.45 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 29 | 0 | 2 | 4 | 6.41 | .407 | 1.99 | 11.1 | 7.3 | 8.7 | 26.2 | 32 | 21 | 19 | 2 | 21 | 25 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.73 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 10 | 0 | 0 | 2 | 7.71 | .417 | 2.14 | 14.0 | 6.0 | 8.0 | 9.1 | 14 | 8 | 8 | 1 | 6 | 8 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.67 |