| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 32 | 32 | 17 | 8 | 3.17 | .253 | 0.99 | 7.4 | 1.5 | 8.2 | 218.1 | 180 | 80 | 77 | 25 | 37 | 199 | 0 | 0 | 0 | 0 | 23 | 5 | 0 | 3.24 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 30 | 30 | 12 | 8 | 4.44 | .300 | 1.26 | 8.9 | 2.5 | 6.9 | 192.2 | 189 | 97 | 95 | 28 | 54 | 147 | 6 | 0 | 0 | 0 | 16 | 5 | 5 | 4.29 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 80 | 0 | 7 | 0 | 1.45 | .202 | 0.76 | 4.4 | 2.5 | 7.9 | 93.1 | 45 | 16 | 15 | 10 | 26 | 82 | 0 | 10 | 2 | 0 | 0 | 0 | 0 | 3.47 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 91 | 75 | 0 | 5 | 7 | 2.74 | .247 | 0.97 | 6.5 | 2.3 | 8.1 | 72.1 | 52 | 22 | 22 | 9 | 18 | 65 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.61 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 58 | 0 | 0 | 7 | 3.98 | .288 | 1.21 | 6.8 | 4.2 | 5.2 | 54.1 | 41 | 24 | 24 | 11 | 25 | 31 | 0 | 18 | 2 | 0 | 0 | 0 | 0 | 5.89 |
| RP | Hoffman, T.Hoffman, Trevor # >> | 31 | 1998 | R | 75 | 33 | 0 | 3 | 3 | 4.54 | .313 | 1.37 | 7.6 | 4.9 | 9.3 | 33.2 | 28 | 17 | 17 | 2 | 18 | 34 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 3.36 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 24 | 0 | 1 | 0 | 2.17 | .263 | 1.04 | 7.3 | 2.2 | 8.3 | 37.1 | 30 | 9 | 9 | 4 | 9 | 34 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.38 |