| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 13 | 6 | 3.65 | .286 | 1.18 | 7.1 | 3.5 | 9.7 | 158.0 | 125 | 67 | 64 | 17 | 61 | 171 | 0 | 0 | 0 | 0 | 18 | 4 | 0 | 3.47 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 25 | 25 | 11 | 9 | 4.76 | .313 | 1.35 | 9.3 | 2.9 | 7.9 | 153.0 | 158 | 81 | 81 | 18 | 49 | 135 | 3 | 0 | 0 | 1 | 13 | 2 | 1 | 3.76 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 24 | 24 | 7 | 7 | 4.90 | .327 | 1.46 | 9.7 | 3.5 | 5.3 | 119.1 | 128 | 66 | 65 | 21 | 46 | 70 | 0 | 0 | 0 | 0 | 7 | 0 | 2 | 5.28 |
| SP | Horlen, J.Horlen, Joe † >> | 27 | 1964 | R | 78 | 24 | 24 | 15 | 4 | 4.19 | .308 | 1.31 | 8.1 | 3.8 | 6.3 | 156.2 | 141 | 75 | 73 | 18 | 65 | 109 | 1 | 0 | 0 | 0 | 15 | 3 | 3 | 4.41 |
| SP | Marquard, R.Marquard, Rube >> | 25 | 1911 | L | 11 | 23 | 23 | 11 | 6 | 5.68 | .339 | 1.52 | 9.4 | 4.3 | 5.9 | 123.2 | 129 | 80 | 78 | 19 | 59 | 81 | 0 | 0 | 0 | 0 | 8 | 2 | 4 | 5.18 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 58 | 0 | 1 | 1 | 3.23 | .250 | 0.97 | 4.9 | 3.8 | 12.4 | 64.0 | 35 | 25 | 23 | 5 | 27 | 88 | 0 | 5 | 4 | 0 | 0 | 2 | 3 | 2.63 |
| CL | Eckersley, D.Eckersley, Dennis † $$ >> | 36 | 1990 | R | 88 | 61 | 0 | 5 | 7 | 3.03 | .302 | 1.30 | 10.2 | 1.6 | 9.0 | 62.1 | 70 | 22 | 21 | 4 | 11 | 62 | 0 | 32 | 4 | 0 | 0 | 0 | 0 | 2.37 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 58 | 0 | 2 | 0 | 4.80 | .321 | 1.39 | 8.9 | 3.7 | 8.6 | 65.2 | 64 | 35 | 35 | 6 | 27 | 62 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 3.63 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 44 | 0 | 5 | 2 | 3.99 | .299 | 1.27 | 7.3 | 4.1 | 5.0 | 79.0 | 64 | 35 | 35 | 9 | 36 | 44 | 0 | 3 | 0 | 0 | 0 | 1 | 5 | 4.77 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 70 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |