| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 16 | 16 | 5 | 5 | 2.96 | .288 | 1.20 | 6.6 | 4.2 | 8.1 | 106.1 | 78 | 36 | 35 | 10 | 50 | 95 | 1 | 0 | 0 | 0 | 11 | 1 | 2 | 3.88 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 16 | 16 | 6 | 4 | 4.38 | .338 | 1.49 | 10.0 | 3.5 | 5.5 | 102.2 | 113 | 60 | 50 | 11 | 40 | 62 | 0 | 0 | 0 | 0 | 8 | 4 | 4 | 4.48 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 16 | 16 | 3 | 8 | 5.27 | .310 | 1.31 | 9.0 | 2.9 | 4.6 | 85.1 | 85 | 51 | 50 | 8 | 27 | 43 | 1 | 0 | 0 | 0 | 7 | 3 | 2 | 4.27 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 16 | 16 | 5 | 9 | 4.85 | .346 | 1.58 | 10.0 | 4.2 | 6.1 | 98.1 | 109 | 54 | 53 | 18 | 46 | 66 | 2 | 0 | 0 | 0 | 8 | 1 | 1 | 5.48 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 92 | 45 | 0 | 1 | 2 | 4.47 | .273 | 1.11 | 6.1 | 4.0 | 9.5 | 52.1 | 35 | 27 | 26 | 2 | 23 | 55 | 0 | 2 | 2 | 0 | 0 | 1 | 4 | 2.77 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 37 | 0 | 4 | 3 | 5.35 | .327 | 1.41 | 10.2 | 2.4 | 9.0 | 37.0 | 42 | 22 | 22 | 8 | 10 | 37 | 0 | 14 | 3 | 0 | 0 | 2 | 0 | 4.78 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 83 | 49 | 0 | 3 | 0 | 4.00 | .289 | 1.17 | 6.9 | 3.7 | 6.3 | 63.0 | 48 | 28 | 28 | 5 | 26 | 44 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 4.02 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 40 | 0 | 6 | 1 | 2.22 | .291 | 1.18 | 7.4 | 3.3 | 10.4 | 52.2 | 43 | 13 | 13 | 4 | 19 | 60 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 2.96 |
| RP | Cordero, F.Cordero, Francisco >> | 27 | 2002 | R | 23 | 24 | 0 | 1 | 3 | 5.40 | .302 | 1.30 | 9.0 | 2.7 | 5.1 | 30.0 | 30 | 18 | 18 | 4 | 9 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |