| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 21 | 21 | 7 | 14 | 4.52 | .306 | 1.30 | 8.3 | 3.4 | 8.6 | 151.1 | 140 | 79 | 76 | 14 | 57 | 145 | 1 | 0 | 0 | 0 | 13 | 3 | 0 | 3.48 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 21 | 21 | 2 | 8 | 5.23 | .334 | 1.51 | 9.2 | 4.4 | 9.6 | 93.0 | 95 | 54 | 54 | 18 | 45 | 99 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 4.84 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 71 | 20 | 20 | 5 | 13 | 5.04 | .345 | 1.57 | 10.3 | 3.8 | 6.6 | 121.1 | 139 | 82 | 68 | 19 | 51 | 89 | 0 | 0 | 0 | 0 | 5 | 2 | 3 | 4.88 |
| SP | Higuera, T.Higuera, Teddy # >> | 30 | 1988 | L | 65 | 20 | 20 | 9 | 9 | 4.35 | .300 | 1.27 | 9.2 | 2.3 | 6.6 | 155.1 | 159 | 79 | 75 | 17 | 39 | 113 | 8 | 0 | 0 | 2 | 9 | 2 | 0 | 3.76 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 58 | 20 | 20 | 5 | 10 | 5.99 | .335 | 1.49 | 11.0 | 2.4 | 6.3 | 141.1 | 172 | 99 | 94 | 25 | 38 | 99 | 2 | 0 | 0 | 0 | 7 | 4 | 4 | 4.79 |
| RP | Green, C.Green, Chad † >> | 26 | 2017 | R | 94 | 54 | 0 | 2 | 2 | 2.40 | .266 | 1.04 | 6.2 | 3.2 | 10.6 | 90.0 | 62 | 26 | 24 | 8 | 32 | 106 | 0 | 12 | 0 | 0 | 0 | 4 | 0 | 3.00 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 32 | 0 | 3 | 2 | 2.18 | .295 | 1.26 | 6.4 | 5.0 | 10.8 | 45.1 | 32 | 11 | 11 | 6 | 25 | 54 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 48 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Strider, S.Strider, Spencer >> | 24 | 2023 | R | 38 | 3 | 0 | 0 | 0 | 14.21 | .441 | 2.21 | 15.0 | 6.0 | 7.5 | 6.1 | 10 | 10 | 10 | 3 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 10.33 |