| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 21 | 21 | 7 | 9 | 4.61 | .292 | 1.21 | 8.4 | 2.6 | 9.5 | 144.1 | 134 | 75 | 74 | 24 | 41 | 152 | 4 | 0 | 0 | 0 | 10 | 4 | 4 | 3.99 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 20 | 20 | 7 | 11 | 5.53 | .345 | 1.56 | 10.1 | 4.0 | 9.7 | 120.1 | 135 | 76 | 74 | 15 | 53 | 129 | 2 | 0 | 0 | 0 | 10 | 2 | 0 | 3.85 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 68 | 20 | 20 | 11 | 5 | 4.18 | .298 | 1.25 | 7.1 | 4.2 | 9.1 | 122.2 | 96 | 59 | 57 | 16 | 57 | 124 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 4.15 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 60 | 20 | 20 | 11 | 6 | 4.51 | .306 | 1.32 | 7.6 | 4.3 | 6.9 | 143.2 | 121 | 73 | 72 | 20 | 69 | 109 | 8 | 0 | 0 | 1 | 9 | 0 | 0 | 4.74 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 56 | 0 | 2 | 0 | 3.08 | .275 | 1.13 | 6.6 | 3.5 | 9.8 | 79.0 | 58 | 28 | 27 | 7 | 31 | 86 | 0 | 6 | 1 | 0 | 0 | 1 | 1 | 3.19 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 79 | 47 | 0 | 3 | 3 | 3.10 | .311 | 1.32 | 8.0 | 4.0 | 7.4 | 52.1 | 46 | 25 | 18 | 9 | 23 | 43 | 0 | 13 | 3 | 0 | 0 | 2 | 3 | 5.04 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 63 | 29 | 0 | 4 | 2 | 6.52 | .331 | 1.45 | 8.7 | 4.3 | 11.8 | 29.0 | 28 | 23 | 21 | 3 | 14 | 38 | 0 | 6 | 2 | 0 | 0 | 1 | 3 | 3.28 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 55 | 22 | 0 | 1 | 1 | 6.04 | .345 | 1.58 | 7.6 | 6.8 | 7.9 | 25.1 | 21 | 18 | 17 | 4 | 19 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 5.60 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 51 | 10 | 0 | 0 | 1 | 5.65 | .377 | 1.81 | 15.4 | 1.3 | 5.8 | 14.1 | 24 | 10 | 9 | 2 | 2 | 9 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.00 |