| SP | Kershaw, C.Kershaw, Clayton † $ >> | 28 | 2016 | L | 98 | 34 | 34 | 17 | 10 | 3.58 | .285 | 1.17 | 8.4 | 2.2 | 8.7 | 241.2 | 224 | 97 | 96 | 29 | 59 | 234 | 4 | 0 | 0 | 2 | 21 | 6 | 4 | 3.43 |
| SP | Santana, J.Santana, Johan $$ >> | 25 | 2004 | L | 91 | 33 | 33 | 13 | 15 | 4.96 | .324 | 1.41 | 8.7 | 3.9 | 9.3 | 212.1 | 206 | 119 | 117 | 42 | 93 | 219 | 1 | 0 | 0 | 0 | 17 | 7 | 4 | 4.92 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 31 | 31 | 17 | 8 | 4.39 | .275 | 1.13 | 7.6 | 2.5 | 8.9 | 199.0 | 169 | 99 | 97 | 39 | 55 | 196 | 1 | 0 | 0 | 0 | 15 | 2 | 5 | 4.44 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 67 | 0 | 2 | 8 | 3.14 | .247 | 0.97 | 6.0 | 2.7 | 11.4 | 63.0 | 42 | 22 | 22 | 8 | 19 | 80 | 0 | 48 | 2 | 0 | 0 | 1 | 1 | 3.06 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 52 | 0 | 1 | 1 | 3.50 | .283 | 1.13 | 6.0 | 4.2 | 10.5 | 54.0 | 36 | 22 | 21 | 5 | 25 | 63 | 0 | 0 | 6 | 0 | 0 | 3 | 0 | 3.43 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 73 | 0 | 2 | 3 | 3.00 | .264 | 1.06 | 6.7 | 2.9 | 9.2 | 93.0 | 69 | 31 | 31 | 12 | 30 | 95 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 3.63 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 57 | 0 | 6 | 2 | 2.49 | .290 | 1.16 | 8.6 | 1.9 | 10.5 | 61.1 | 58 | 17 | 17 | 10 | 13 | 71 | 0 | 0 | 2 | 0 | 0 | 4 | 0 | 3.64 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 31 | 0 | 0 | 0 | 3.00 | .288 | 1.18 | 6.0 | 4.6 | 10.6 | 33.0 | 22 | 11 | 11 | 2 | 17 | 39 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.06 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 70 | 16 | 0 | 2 | 3 | 5.88 | .330 | 1.42 | 9.6 | 3.4 | 6.4 | 59.2 | 63 | 39 | 39 | 8 | 22 | 42 | 0 | 0 | 1 | 0 | 0 | 3 | 1 | 4.61 |