| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 32 | 32 | 13 | 15 | 2.90 | .268 | 1.09 | 7.9 | 1.9 | 9.1 | 236.0 | 208 | 82 | 76 | 29 | 49 | 238 | 9 | 0 | 0 | 2 | 22 | 2 | 3 | 3.23 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 82 | 31 | 31 | 11 | 8 | 3.93 | .294 | 1.22 | 7.3 | 3.7 | 8.7 | 192.1 | 155 | 84 | 84 | 25 | 79 | 186 | 2 | 0 | 0 | 1 | 16 | 6 | 2 | 4.08 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 31 | 31 | 9 | 12 | 5.20 | .353 | 1.62 | 10.4 | 4.2 | 9.0 | 209.1 | 242 | 128 | 121 | 36 | 97 | 208 | 2 | 0 | 0 | 0 | 14 | 4 | 6 | 4.70 |
| SP | Saberhagen, B.Saberhagen, Bret # >> | 25 | 1989 | R | 64 | 30 | 30 | 9 | 15 | 5.35 | .313 | 1.34 | 9.5 | 2.6 | 6.5 | 205.1 | 217 | 126 | 122 | 32 | 59 | 147 | 0 | 0 | 0 | 0 | 12 | 5 | 4 | 4.53 |
| SP | Sheets, B.Sheets, Ben # >> | 26 | 2004 | R | 56 | 27 | 27 | 9 | 13 | 5.67 | .334 | 1.47 | 10.6 | 2.7 | 10.8 | 177.2 | 208 | 113 | 112 | 35 | 53 | 212 | 1 | 0 | 0 | 0 | 10 | 6 | 5 | 4.18 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 83 | 72 | 0 | 6 | 4 | 1.98 | .230 | 0.89 | 5.9 | 2.2 | 9.7 | 81.2 | 53 | 18 | 18 | 5 | 20 | 87 | 0 | 10 | 3 | 0 | 0 | 0 | 0 | 2.40 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 50 | 0 | 6 | 5 | 2.48 | .251 | 0.96 | 4.9 | 3.8 | 9.4 | 61.2 | 33 | 17 | 17 | 6 | 26 | 64 | 0 | 4 | 0 | 0 | 0 | 3 | 1 | 3.61 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 53 | 26 | 0 | 2 | 1 | 2.76 | .263 | 1.01 | 7.6 | 1.7 | 9.8 | 32.2 | 27 | 11 | 10 | 6 | 6 | 35 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.00 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 3 | 2 | 0 | 1 | 3.65 | .327 | 1.46 | 9.0 | 4.5 | 7.5 | 12.1 | 12 | 5 | 5 | 1 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.92 |