| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 33 | 33 | 11 | 12 | 4.12 | .289 | 1.17 | 8.1 | 2.5 | 9.7 | 207.1 | 186 | 98 | 95 | 31 | 57 | 222 | 1 | 0 | 0 | 1 | 15 | 10 | 0 | 3.77 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 85 | 32 | 32 | 5 | 13 | 6.01 | .346 | 1.54 | 10.0 | 3.8 | 4.9 | 155.2 | 173 | 110 | 104 | 20 | 66 | 85 | 0 | 0 | 0 | 0 | 4 | 8 | 4 | 5.01 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 31 | 31 | 9 | 12 | 5.65 | .346 | 1.56 | 10.6 | 3.5 | 5.8 | 200.2 | 236 | 137 | 126 | 32 | 78 | 128 | 10 | 0 | 0 | 1 | 14 | 5 | 8 | 5.05 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 30 | 30 | 6 | 17 | 6.61 | .350 | 1.59 | 11.6 | 2.7 | 4.5 | 181.0 | 233 | 143 | 133 | 27 | 55 | 91 | 1 | 0 | 0 | 1 | 9 | 4 | 3 | 4.91 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 83 | 0 | 6 | 9 | 4.08 | .281 | 1.14 | 7.4 | 2.8 | 8.6 | 117.0 | 96 | 57 | 53 | 16 | 37 | 112 | 0 | 6 | 7 | 0 | 0 | 4 | 0 | 3.91 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 80 | 0 | 3 | 9 | 4.11 | .294 | 1.20 | 8.7 | 2.1 | 8.3 | 116.0 | 112 | 54 | 53 | 13 | 27 | 107 | 0 | 6 | 1 | 0 | 0 | 6 | 0 | 3.47 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 77 | 0 | 4 | 5 | 4.61 | .323 | 1.42 | 9.1 | 3.8 | 7.3 | 95.2 | 96 | 50 | 49 | 18 | 40 | 77 | 0 | 4 | 3 | 0 | 0 | 1 | 3 | 5.14 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 61 | 63 | 0 | 3 | 1 | 3.32 | .278 | 1.16 | 7.2 | 3.3 | 8.5 | 78.2 | 62 | 31 | 29 | 8 | 29 | 74 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 3.55 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |