| SP | Tiant, L.Tiant, Luis $ >> | 28 | 1968 | R | 97 | 33 | 33 | 17 | 9 | 2.61 | .267 | 1.06 | 6.3 | 3.3 | 7.5 | 248.0 | 174 | 85 | 72 | 16 | 90 | 207 | 2 | 0 | 0 | 2 | 23 | 7 | 2 | 3.34 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 32 | 32 | 12 | 13 | 3.78 | .269 | 1.07 | 7.4 | 2.2 | 7.4 | 209.2 | 173 | 88 | 88 | 29 | 51 | 171 | 1 | 0 | 0 | 0 | 21 | 8 | 2 | 4.01 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 85 | 32 | 32 | 23 | 3 | 2.76 | .261 | 1.03 | 7.2 | 2.1 | 4.3 | 257.2 | 205 | 87 | 79 | 24 | 60 | 122 | 12 | 0 | 0 | 5 | 20 | 8 | 4 | 4.06 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 31 | 31 | 16 | 6 | 4.52 | .322 | 1.38 | 9.0 | 3.4 | 7.1 | 189.0 | 189 | 99 | 95 | 18 | 72 | 150 | 0 | 0 | 0 | 0 | 14 | 8 | 3 | 3.92 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 76 | 0 | 3 | 3 | 2.39 | .296 | 1.23 | 6.2 | 4.9 | 7.7 | 90.1 | 62 | 28 | 24 | 8 | 49 | 77 | 0 | 16 | 3 | 0 | 0 | 3 | 2 | 4.18 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 65 | 0 | 5 | 5 | 3.77 | .286 | 1.19 | 7.2 | 3.5 | 9.5 | 71.2 | 57 | 30 | 30 | 7 | 28 | 75 | 0 | 10 | 3 | 0 | 0 | 1 | 0 | 3.39 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 43 | 0 | 6 | 5 | 2.26 | .236 | 0.93 | 6.0 | 2.5 | 9.7 | 51.2 | 34 | 13 | 13 | 2 | 14 | 55 | 0 | 6 | 4 | 0 | 0 | 0 | 0 | 2.18 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 22 | 0 | 0 | 2 | 4.74 | .352 | 1.58 | 8.5 | 5.7 | 9.9 | 19.0 | 18 | 10 | 10 | 5 | 12 | 21 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 6.26 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 29 | 0 | 4 | 0 | 1.91 | .272 | 1.12 | 4.4 | 5.7 | 4.9 | 33.0 | 16 | 7 | 7 | 2 | 21 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.61 |