| SP | Cortes Jr., N.Cortes Jr., Nestor >> | 27 | 2022 | L | 100 | 21 | 21 | 7 | 7 | 6.36 | .371 | 1.72 | 12.4 | 3.1 | 10.2 | 103.1 | 142 | 74 | 73 | 13 | 36 | 117 | 0 | 0 | 0 | 0 | 7 | 5 | 4 | 3.56 |
| SP | Severino, L.Severino, Luis >> | 28 | 2022 | R | 91 | 19 | 19 | 8 | 5 | 4.46 | .321 | 1.39 | 9.6 | 2.9 | 9.7 | 107.0 | 114 | 55 | 53 | 15 | 35 | 115 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 3.74 |
| SP | Cole, G.Cole, Gerrit † >> | 31 | 2022 | R | 85 | 21 | 21 | 12 | 3 | 3.35 | .288 | 1.19 | 8.1 | 2.6 | 10.0 | 137.0 | 124 | 55 | 51 | 18 | 39 | 152 | 1 | 0 | 0 | 1 | 15 | 3 | 2 | 3.41 |
| SP | Sabathia, C.Sabathia, CC >> | 29 | 2009 | L | 49 | 20 | 20 | 10 | 5 | 4.80 | .322 | 1.40 | 8.9 | 3.7 | 6.4 | 131.1 | 130 | 71 | 70 | 16 | 54 | 93 | 2 | 0 | 0 | 0 | 11 | 3 | 8 | 4.47 |
| SP | Guidry, R.Guidry, Ron # >> | 35 | 1985 | L | 43 | 20 | 20 | 7 | 6 | 5.69 | .322 | 1.38 | 10.2 | 2.2 | 6.2 | 125.0 | 142 | 81 | 79 | 27 | 30 | 86 | 2 | 0 | 0 | 0 | 8 | 6 | 2 | 5.30 |
| CL | Marinaccio, R.Marinaccio, Ron † >> | 26 | 2022 | R | 89 | 46 | 0 | 2 | 3 | 4.47 | .367 | 1.71 | 9.8 | 5.7 | 11.3 | 44.1 | 48 | 22 | 22 | 3 | 28 | 55 | 0 | 23 | 4 | 0 | 0 | 1 | 2 | 3.36 |
| RP | Rivera, M.Rivera, Mariano >> | 40 | 2009 | R | 86 | 55 | 0 | 5 | 2 | 4.48 | .320 | 1.38 | 9.9 | 2.6 | 10.2 | 60.1 | 66 | 31 | 30 | 9 | 17 | 68 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 3.63 |
| RP | Holmes, C.Holmes, Clay >> | 29 | 2022 | R | 76 | 36 | 0 | 1 | 1 | 3.38 | .273 | 1.13 | 7.7 | 2.6 | 8.2 | 34.2 | 29 | 14 | 13 | 3 | 10 | 31 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.21 |
| RP | Peralta, W.Peralta, Wandy >> | 30 | 2022 | L | 62 | 47 | 0 | 2 | 0 | 4.20 | .358 | 1.67 | 11.0 | 4.3 | 7.4 | 40.2 | 49 | 19 | 19 | 5 | 19 | 33 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.40 |