| SP | Peralta, F.Peralta, Freddy >> | 25 | 2021 | R | 99 | 21 | 21 | 8 | 3 | 4.66 | .315 | 1.32 | 8.2 | 3.7 | 8.6 | 110.0 | 100 | 57 | 57 | 15 | 45 | 105 | 0 | 0 | 0 | 0 | 7 | 7 | 3 | 4.28 |
| SP | Burnes, C.Burnes, Corbin >> | 26 | 2021 | R | 94 | 20 | 20 | 8 | 5 | 3.56 | .287 | 1.16 | 7.4 | 3.1 | 10.0 | 129.0 | 106 | 54 | 51 | 16 | 44 | 143 | 0 | 0 | 0 | 0 | 14 | 6 | 3 | 3.56 |
| SP | Woodruff, B.Woodruff, Brandon >> | 28 | 2021 | R | 93 | 20 | 20 | 8 | 8 | 4.83 | .301 | 1.28 | 9.7 | 1.8 | 10.2 | 123.0 | 132 | 70 | 66 | 21 | 25 | 139 | 1 | 0 | 0 | 1 | 9 | 2 | 0 | 3.62 |
| SP | Chacin, J.Chacin, Jhoulys >> | 30 | 2018 | R | 50 | 19 | 19 | 9 | 1 | 3.61 | .300 | 1.28 | 7.5 | 4.0 | 8.1 | 107.1 | 89 | 47 | 43 | 17 | 48 | 96 | 0 | 0 | 0 | 0 | 7 | 1 | 5 | 4.64 |
| SP | Greinke, Z.Greinke, Zack # >> | 28 | 2011 | R | 30 | 19 | 19 | 6 | 9 | 5.81 | .349 | 1.57 | 11.2 | 2.9 | 9.4 | 110.0 | 137 | 74 | 71 | 17 | 36 | 115 | 0 | 0 | 0 | 0 | 6 | 4 | 4 | 4.01 |
| RP | Jeffress, J.Jeffress, Jeremy † >> | 30 | 2018 | R | 88 | 48 | 0 | 6 | 4 | 2.66 | .275 | 1.12 | 6.4 | 3.8 | 9.7 | 67.2 | 48 | 21 | 20 | 4 | 28 | 72 | 0 | 4 | 3 | 0 | 0 | 1 | 2 | 2.93 |
| RP | Knebel, C.Knebel, Corey >> | 26 | 2018 | R | 71 | 44 | 0 | 1 | 2 | 2.58 | .267 | 1.06 | 5.9 | 3.7 | 11.9 | 59.1 | 39 | 17 | 17 | 8 | 24 | 78 | 0 | 3 | 2 | 0 | 0 | 2 | 0 | 3.44 |
| RP | Fingers, R.Fingers, Rollie >> | 36 | 1982 | R | 54 | 42 | 0 | 2 | 1 | 3.04 | .346 | 1.56 | 9.4 | 4.8 | 7.1 | 47.1 | 49 | 20 | 16 | 2 | 25 | 37 | 0 | 11 | 4 | 0 | 0 | 1 | 2 | 3.64 |
| RP | Axford, J.Axford, John >> | 28 | 2011 | R | 43 | 21 | 0 | 0 | 1 | 1.66 | .270 | 1.11 | 8.1 | 2.1 | 8.6 | 21.2 | 19 | 4 | 4 | 2 | 5 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.05 |
| RP | Bernard, D.Bernard, Dwight >> | 30 | 1982 | R | 18 | 22 | 0 | 1 | 3 | 2.38 | .292 | 1.21 | 8.7 | 2.1 | 7.4 | 34.0 | 33 | 9 | 9 | 3 | 8 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.29 |
| SP | Gallardo, Y.Gallardo, Yovani >> | 25 | 2011 | R | 24 | 4 | 0 | 1 | 1 | 1.50 | .357 | 1.67 | 12.0 | 3.0 | 7.5 | 6.0 | 8 | 4 | 1 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.33 |