| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 25 | 25 | 11 | 8 | 3.55 | .272 | 1.09 | 6.3 | 3.5 | 9.9 | 172.1 | 121 | 68 | 68 | 24 | 66 | 190 | 1 | 0 | 0 | 1 | 18 | 6 | 4 | 3.86 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 24 | 24 | 9 | 12 | 4.86 | .319 | 1.38 | 9.6 | 2.9 | 8.2 | 163.0 | 173 | 89 | 88 | 28 | 52 | 149 | 4 | 0 | 0 | 0 | 10 | 4 | 3 | 4.44 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 24 | 24 | 2 | 8 | 5.20 | .334 | 1.48 | 8.9 | 4.4 | 10.7 | 100.1 | 99 | 61 | 58 | 25 | 49 | 119 | 0 | 0 | 0 | 0 | 0 | 3 | 5 | 5.43 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 74 | 24 | 24 | 9 | 13 | 4.55 | .318 | 1.38 | 9.1 | 3.3 | 6.8 | 186.0 | 188 | 99 | 94 | 31 | 68 | 141 | 10 | 0 | 0 | 2 | 10 | 4 | 0 | 4.81 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 73 | 24 | 24 | 7 | 14 | 6.04 | .331 | 1.47 | 10.4 | 2.8 | 6.4 | 143.0 | 166 | 110 | 96 | 34 | 44 | 102 | 0 | 0 | 0 | 0 | 10 | 2 | 0 | 5.63 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 63 | 0 | 4 | 1 | 2.28 | .279 | 1.15 | 6.3 | 4.1 | 10.8 | 94.2 | 66 | 24 | 24 | 7 | 43 | 113 | 0 | 6 | 2 | 0 | 0 | 1 | 2 | 2.97 |
| RP | Jackson, M.Jackson, Mike † >> | 30 | 1994 | R | 82 | 61 | 0 | 11 | 1 | 2.42 | .247 | 0.98 | 5.2 | 3.6 | 9.5 | 74.1 | 43 | 20 | 20 | 8 | 30 | 78 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 3.51 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 82 | 52 | 0 | 0 | 3 | 3.60 | .283 | 1.17 | 6.6 | 3.9 | 11.4 | 60.0 | 44 | 24 | 24 | 10 | 26 | 76 | 0 | 6 | 1 | 0 | 0 | 1 | 3 | 3.98 |
| RP | Gallegos, G.Gallegos, Giovanny # >> | 27 | 2019 | R | 78 | 37 | 0 | 2 | 3 | 4.91 | .279 | 1.14 | 7.0 | 3.3 | 10.6 | 44.0 | 34 | 24 | 24 | 7 | 16 | 52 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 3.86 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 26 | 0 | 0 | 2 | 3.41 | .275 | 1.07 | 7.8 | 2.0 | 8.4 | 31.2 | 27 | 12 | 12 | 4 | 7 | 29 | 0 | 3 | 0 | 0 | 0 | 2 | 2 | 3.68 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 88 | 10 | 0 | 0 | 1 | 4.50 | .368 | 1.63 | 10.1 | 4.5 | 5.6 | 8.0 | 9 | 4 | 4 | 2 | 4 | 5 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 6.88 |