| SP | Tiant, L.Tiant, Luis $$ >> | 28 | 1968 | R | 97 | 28 | 28 | 10 | 12 | 4.47 | .307 | 1.31 | 7.5 | 4.3 | 7.3 | 189.1 | 158 | 103 | 94 | 15 | 90 | 154 | 2 | 0 | 0 | 0 | 15 | 4 | 2 | 3.89 |
| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 28 | 28 | 13 | 9 | 4.33 | .289 | 1.20 | 8.7 | 2.1 | 5.4 | 210.0 | 202 | 101 | 101 | 30 | 50 | 125 | 7 | 0 | 0 | 1 | 12 | 4 | 2 | 4.44 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 27 | 27 | 10 | 7 | 3.97 | .289 | 1.20 | 7.8 | 2.9 | 7.7 | 177.0 | 154 | 85 | 78 | 18 | 58 | 152 | 2 | 0 | 0 | 1 | 16 | 4 | 7 | 3.66 |
| SP | Cueto, J.Cueto, Johnny † # >> | 28 | 2014 | R | 75 | 27 | 27 | 17 | 8 | 3.69 | .282 | 1.15 | 8.2 | 2.2 | 7.9 | 195.0 | 178 | 82 | 80 | 27 | 47 | 171 | 8 | 0 | 0 | 1 | 15 | 5 | 3 | 3.85 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 70 | 0 | 3 | 5 | 2.99 | .278 | 1.14 | 8.2 | 2.1 | 8.8 | 81.1 | 74 | 31 | 27 | 12 | 19 | 79 | 0 | 12 | 6 | 0 | 0 | 1 | 2 | 3.72 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 28 | 0 | 2 | 4 | 3.00 | .256 | 1.03 | 6.3 | 3.0 | 6.8 | 33.0 | 23 | 12 | 11 | 2 | 11 | 25 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 3.27 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 16 | 0 | 2 | 1 | 4.67 | .342 | 1.56 | 7.4 | 6.9 | 8.5 | 17.1 | 14 | 11 | 9 | 2 | 13 | 16 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.94 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 19 | 0 | 0 | 1 | 4.82 | .356 | 1.66 | 10.5 | 5.0 | 7.5 | 18.2 | 21 | 10 | 10 | 2 | 10 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 4.44 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 14 | 0 | 0 | 2 | 4.73 | .324 | 1.43 | 9.3 | 3.7 | 8.3 | 66.2 | 68 | 37 | 35 | 10 | 27 | 61 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.39 |