| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 28 | 28 | 12 | 9 | 3.82 | .297 | 1.24 | 8.8 | 2.4 | 8.3 | 219.1 | 213 | 96 | 93 | 19 | 59 | 201 | 14 | 0 | 0 | 1 | 15 | 6 | 7 | 3.18 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 28 | 28 | 14 | 9 | 3.75 | .279 | 1.14 | 8.1 | 2.2 | 5.3 | 201.2 | 181 | 88 | 84 | 17 | 49 | 118 | 8 | 0 | 0 | 4 | 16 | 4 | 0 | 3.72 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 27 | 27 | 12 | 7 | 4.88 | .323 | 1.41 | 8.7 | 4.0 | 5.6 | 158.2 | 153 | 93 | 86 | 21 | 71 | 98 | 0 | 0 | 0 | 0 | 12 | 3 | 6 | 4.89 |
| SP | Guidry, R.Guidry, Ron † # >> | 28 | 1978 | L | 77 | 27 | 27 | 18 | 8 | 2.95 | .256 | 1.01 | 6.7 | 2.4 | 6.0 | 213.2 | 159 | 76 | 70 | 16 | 57 | 143 | 14 | 0 | 0 | 6 | 16 | 4 | 5 | 3.49 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 58 | 0 | 8 | 1 | 2.55 | .247 | 0.98 | 5.6 | 3.3 | 9.2 | 91.2 | 57 | 26 | 26 | 9 | 33 | 93 | 0 | 8 | 4 | 0 | 0 | 0 | 0 | 3.33 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 41 | 0 | 5 | 2 | 3.54 | .299 | 1.25 | 5.9 | 5.6 | 7.2 | 40.2 | 26 | 19 | 16 | 5 | 25 | 32 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 4.98 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 24 | 0 | 2 | 0 | 3.65 | .339 | 1.54 | 9.4 | 4.9 | 12.0 | 24.2 | 25 | 11 | 10 | 1 | 13 | 32 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 2.50 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 5 | 0 | 0 | 0 | 1.59 | .190 | 0.71 | 5.4 | 1.8 | 18.0 | 5.2 | 3 | 1 | 1 | 1 | 1 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.20 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 7 | 0 | 0 | 0 | 1.00 | .250 | 0.89 | 6.0 | 2.0 | 5.0 | 9.0 | 6 | 1 | 1 | 0 | 2 | 5 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2.89 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 12 | 0 | 1 | 1 | 1.10 | .197 | 0.73 | 5.6 | 1.1 | 6.2 | 16.1 | 10 | 3 | 2 | 1 | 2 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.81 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 15 | 0 | 0 | 1 | 3.45 | .263 | 1.07 | 7.8 | 1.8 | 6.8 | 73.0 | 63 | 39 | 28 | 5 | 15 | 55 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.00 |