| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 27 | 27 | 10 | 11 | 5.00 | .320 | 1.39 | 9.8 | 2.7 | 4.5 | 171.0 | 186 | 96 | 95 | 16 | 52 | 85 | 1 | 0 | 0 | 1 | 12 | 3 | 2 | 4.19 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 28 | 27 | 10 | 11 | 6.18 | .348 | 1.59 | 11.2 | 3.1 | 7.9 | 182.0 | 227 | 129 | 125 | 30 | 63 | 160 | 3 | 0 | 0 | 1 | 7 | 2 | 6 | 4.46 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 27 | 26 | 5 | 7 | 6.29 | .352 | 1.60 | 10.9 | 3.6 | 6.5 | 121.2 | 146 | 87 | 85 | 18 | 49 | 88 | 3 | 0 | 0 | 0 | 7 | 3 | 2 | 4.77 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 58 | 0 | 3 | 3 | 4.36 | .340 | 1.52 | 8.0 | 5.6 | 8.9 | 66.0 | 59 | 33 | 32 | 4 | 41 | 65 | 0 | 4 | 2 | 0 | 0 | 2 | 2 | 3.77 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 45 | 0 | 2 | 1 | 4.11 | .281 | 1.13 | 7.4 | 2.9 | 9.9 | 50.1 | 41 | 25 | 23 | 6 | 16 | 55 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.44 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 51 | 0 | 8 | 3 | 5.70 | .329 | 1.47 | 9.2 | 4.2 | 10.5 | 53.2 | 54 | 39 | 34 | 6 | 25 | 62 | 0 | 2 | 3 | 0 | 0 | 0 | 8 | 3.55 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 45 | 0 | 2 | 1 | 5.14 | .360 | 1.64 | 9.4 | 5.4 | 8.8 | 42.0 | 44 | 24 | 24 | 8 | 25 | 41 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 5.45 |
| CL | Doolittle, S.Doolittle, Sean $$ >> | 31 | 2018 | L | 99 | 57 | 0 | 3 | 6 | 2.72 | .239 | 0.93 | 5.8 | 2.6 | 8.5 | 82.2 | 53 | 26 | 25 | 10 | 24 | 77 | 0 | 16 | 6 | 0 | 0 | 1 | 1 | 3.62 |