| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 24 | 24 | 11 | 6 | 3.65 | .302 | 1.29 | 8.8 | 2.9 | 7.9 | 177.2 | 173 | 75 | 72 | 16 | 57 | 156 | 3 | 0 | 0 | 1 | 15 | 1 | 2 | 3.40 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 23 | 23 | 8 | 7 | 3.70 | .290 | 1.21 | 7.9 | 3.0 | 5.0 | 150.2 | 132 | 63 | 62 | 15 | 50 | 83 | 0 | 0 | 0 | 0 | 13 | 3 | 2 | 4.25 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 22 | 22 | 10 | 5 | 3.19 | .274 | 1.10 | 8.3 | 1.6 | 6.1 | 175.0 | 161 | 64 | 62 | 11 | 32 | 118 | 9 | 0 | 0 | 3 | 13 | 5 | 4 | 3.10 |
| SP | Brown, M.Brown, Mordecai $ >> | 32 | 1908 | R | 85 | 22 | 22 | 7 | 10 | 4.17 | .298 | 1.25 | 8.5 | 2.8 | 5.5 | 155.1 | 146 | 78 | 72 | 11 | 48 | 95 | 3 | 0 | 0 | 0 | 11 | 4 | 4 | 3.70 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 57 | 0 | 4 | 5 | 3.00 | .267 | 1.08 | 6.5 | 3.1 | 9.4 | 66.0 | 48 | 22 | 22 | 6 | 23 | 69 | 0 | 12 | 1 | 0 | 0 | 1 | 1 | 3.18 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 23 | 0 | 4 | 4 | 3.00 | .294 | 1.17 | 6.4 | 4.1 | 10.1 | 24.0 | 17 | 9 | 8 | 4 | 11 | 27 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 4.54 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 18 | 0 | 1 | 3 | 4.24 | .370 | 1.76 | 13.2 | 2.6 | 6.4 | 17.0 | 25 | 10 | 8 | 3 | 5 | 12 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 4.76 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 14 | 0 | 1 | 2 | 4.08 | .293 | 1.19 | 6.9 | 4.2 | 6.9 | 17.2 | 13 | 8 | 8 | 1 | 8 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.82 |