| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 33 | 33 | 18 | 14 | 3.60 | .298 | 1.24 | 8.7 | 2.5 | 4.2 | 259.2 | 250 | 117 | 104 | 23 | 73 | 120 | 12 | 0 | 0 | 0 | 22 | 8 | 2 | 4.17 |
| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 53 | 33 | 33 | 12 | 15 | 4.63 | .316 | 1.36 | 9.2 | 3.0 | 5.0 | 223.1 | 228 | 124 | 115 | 33 | 75 | 125 | 1 | 0 | 0 | 1 | 19 | 6 | 5 | 4.89 |
| SP | Newhouser, H.Newhouser, Hal >> | 23 | 1944 | L | 4 | 26 | 26 | 11 | 8 | 4.22 | .321 | 1.41 | 9.1 | 3.7 | 3.9 | 177.0 | 178 | 88 | 83 | 15 | 72 | 77 | 2 | 0 | 0 | 0 | 16 | 1 | 3 | 4.47 |
| SP | Spahn, W.Spahn, Warren # >> | 29 | 1950 | L | 4 | 20 | 20 | 6 | 7 | 4.37 | .317 | 1.35 | 9.0 | 3.1 | 4.8 | 142.0 | 142 | 76 | 69 | 16 | 49 | 76 | 1 | 0 | 0 | 0 | 8 | 7 | 2 | 4.58 |
| SP | Perry, G.Perry, Gaylord >> | 29 | 1967 | R | 22 | 19 | 19 | 6 | 11 | 5.64 | .345 | 1.58 | 10.1 | 4.2 | 4.4 | 134.0 | 150 | 91 | 84 | 20 | 62 | 66 | 3 | 0 | 0 | 1 | 9 | 0 | 6 | 5.34 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 72 | 0 | 5 | 4 | 4.42 | .301 | 1.25 | 9.2 | 2.1 | 7.8 | 77.1 | 79 | 41 | 38 | 10 | 18 | 67 | 0 | 13 | 2 | 0 | 0 | 3 | 3 | 3.77 |
| RP | Mantei, M.Mantei, Matt >> | 25 | 1998 | R | 19 | 24 | 0 | 0 | 1 | 4.94 | .377 | 1.82 | 7.8 | 9.0 | 7.8 | 23.2 | 20 | 13 | 13 | 1 | 23 | 20 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.83 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 34 | 1969 | R | 32 | 19 | 3 | 0 | 1 | 7.04 | .358 | 1.67 | 11.4 | 3.8 | 6.2 | 38.1 | 48 | 30 | 30 | 11 | 16 | 26 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 6.66 |
| SU | Dibble, R.Dibble, Rob # >> | 26 | 1990 | R | 58 | 36 | 0 | 2 | 4 | 4.46 | .316 | 1.39 | 5.9 | 6.8 | 7.4 | 40.1 | 26 | 20 | 20 | 6 | 30 | 33 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 5.55 |
| CL | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 22 | 0 | 3 | 2 | 2.08 | .243 | 0.96 | 4.8 | 3.8 | 9.0 | 26.0 | 14 | 6 | 6 | 1 | 11 | 26 | 0 | 13 | 1 | 0 | 0 | 0 | 1 | 2.77 |