| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 28 | 28 | 8 | 15 | 4.13 | .286 | 1.19 | 7.8 | 3.0 | 8.6 | 209.1 | 180 | 103 | 96 | 34 | 69 | 200 | 8 | 0 | 0 | 1 | 13 | 3 | 3 | 4.23 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 82 | 27 | 27 | 5 | 14 | 4.65 | .312 | 1.33 | 10.2 | 1.8 | 5.3 | 187.2 | 212 | 103 | 97 | 24 | 37 | 111 | 6 | 0 | 0 | 1 | 13 | 6 | 1 | 4.17 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 27 | 27 | 9 | 12 | 4.51 | .327 | 1.42 | 9.8 | 3.0 | 5.2 | 195.2 | 212 | 108 | 98 | 27 | 66 | 112 | 6 | 0 | 0 | 1 | 13 | 7 | 3 | 4.77 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 27 | 27 | 11 | 10 | 4.45 | .305 | 1.30 | 8.8 | 2.9 | 5.6 | 184.0 | 180 | 97 | 91 | 27 | 59 | 115 | 5 | 0 | 0 | 1 | 12 | 3 | 3 | 4.67 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 68 | 0 | 6 | 1 | 2.53 | .261 | 1.05 | 5.6 | 3.9 | 9.3 | 106.2 | 66 | 33 | 30 | 10 | 46 | 109 | 0 | 8 | 1 | 0 | 0 | 1 | 0 | 3.50 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 37 | 0 | 2 | 2 | 4.43 | .333 | 1.48 | 9.9 | 3.6 | 6.1 | 40.2 | 44 | 24 | 20 | 7 | 16 | 27 | 0 | 4 | 1 | 0 | 0 | 1 | 3 | 5.20 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 57 | 30 | 0 | 1 | 0 | 4.35 | .345 | 1.52 | 6.4 | 7.3 | 8.4 | 31.0 | 22 | 15 | 15 | 2 | 25 | 29 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.58 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 3 | 0 | 2 | 0 | 0.00 | .200 | 0.75 | 4.5 | 2.3 | 2.3 | 8.0 | 4 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.25 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 23 | 0 | 3 | 3 | 6.12 | .398 | 1.92 | 12.7 | 4.8 | 5.9 | 32.1 | 45 | 23 | 22 | 5 | 17 | 21 | 0 | 4 | 2 | 0 | 0 | 2 | 1 | 5.50 |