| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 34 | 34 | 14 | 15 | 5.36 | .336 | 1.49 | 10.4 | 3.0 | 9.1 | 205.0 | 236 | 127 | 122 | 34 | 69 | 207 | 1 | 0 | 0 | 0 | 17 | 6 | 4 | 4.23 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 34 | 34 | 10 | 17 | 5.28 | .330 | 1.46 | 9.7 | 3.5 | 8.1 | 211.1 | 228 | 130 | 124 | 39 | 81 | 189 | 2 | 0 | 0 | 0 | 14 | 3 | 2 | 4.81 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 33 | 32 | 6 | 18 | 6.89 | .354 | 1.63 | 11.5 | 3.1 | 7.0 | 188.0 | 241 | 148 | 144 | 31 | 65 | 146 | 0 | 0 | 1 | 0 | 7 | 3 | 1 | 4.68 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 32 | 32 | 8 | 14 | 6.14 | .348 | 1.59 | 10.7 | 3.6 | 5.7 | 192.0 | 228 | 135 | 131 | 39 | 77 | 122 | 4 | 0 | 0 | 0 | 12 | 2 | 5 | 5.60 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 96 | 0 | 4 | 4 | 3.48 | .288 | 1.21 | 6.9 | 4.0 | 8.7 | 134.1 | 103 | 54 | 52 | 13 | 59 | 129 | 0 | 11 | 3 | 0 | 0 | 1 | 1 | 3.68 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 81 | 0 | 6 | 6 | 3.09 | .273 | 1.11 | 7.8 | 2.2 | 8.3 | 105.0 | 91 | 37 | 36 | 10 | 26 | 97 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 3.16 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 69 | 0 | 2 | 3 | 3.75 | .292 | 1.24 | 7.0 | 4.1 | 9.0 | 72.0 | 56 | 31 | 30 | 11 | 33 | 72 | 0 | 7 | 1 | 0 | 0 | 0 | 1 | 4.36 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 53 | 0 | 5 | 3 | 4.72 | .335 | 1.49 | 9.4 | 4.0 | 9.1 | 61.0 | 64 | 34 | 32 | 10 | 27 | 62 | 0 | 3 | 2 | 0 | 0 | 1 | 3 | 4.48 |
| RP | Orosco, J.Orosco, Jesse >> | 26 | 1983 | L | 24 | 52 | 0 | 3 | 1 | 4.82 | .319 | 1.36 | 7.7 | 4.6 | 4.7 | 80.1 | 68 | 43 | 43 | 14 | 41 | 42 | 0 | 6 | 1 | 0 | 0 | 4 | 0 | 5.91 |