| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 38 | 38 | 15 | 12 | 3.13 | .259 | 1.03 | 6.9 | 2.4 | 8.9 | 250.0 | 192 | 98 | 87 | 23 | 66 | 247 | 3 | 0 | 0 | 1 | 25 | 4 | 0 | 3.06 |
| SP | Richard, J.Richard, J.R. $ >> | 30 | 1980 | R | 90 | 37 | 37 | 20 | 5 | 3.10 | .291 | 1.22 | 7.2 | 3.8 | 8.2 | 258.1 | 206 | 98 | 89 | 20 | 108 | 235 | 4 | 0 | 0 | 2 | 26 | 4 | 5 | 3.49 |
| SP | Lundgren, C.Lundgren, Carl † >> | 27 | 1907 | R | 44 | 34 | 34 | 17 | 11 | 2.74 | .280 | 1.15 | 6.3 | 4.0 | 3.6 | 236.1 | 166 | 85 | 72 | 17 | 105 | 95 | 9 | 0 | 0 | 2 | 27 | 5 | 2 | 4.53 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 49 | 34 | 34 | 16 | 9 | 4.32 | .305 | 1.30 | 7.4 | 4.4 | 8.7 | 168.2 | 138 | 86 | 81 | 17 | 82 | 163 | 0 | 0 | 0 | 0 | 14 | 2 | 1 | 3.88 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 98 | 107 | 0 | 2 | 2 | 2.08 | .232 | 0.87 | 5.4 | 2.5 | 8.0 | 95.0 | 57 | 25 | 22 | 6 | 26 | 84 | 0 | 10 | 5 | 0 | 0 | 3 | 0 | 2.97 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 73 | 0 | 4 | 3 | 1.99 | .218 | 0.82 | 4.0 | 3.4 | 8.2 | 58.2 | 26 | 14 | 13 | 5 | 22 | 53 | 0 | 10 | 0 | 0 | 0 | 1 | 2 | 3.48 |
| RP | Davis, W.Davis, Wade # >> | 29 | 2015 | R | 88 | 42 | 0 | 2 | 4 | 4.54 | .272 | 1.12 | 7.7 | 2.6 | 10.0 | 35.2 | 30 | 18 | 18 | 10 | 10 | 39 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 5.34 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 25 | 0 | 4 | 1 | 4.56 | .343 | 1.56 | 9.8 | 4.7 | 8.6 | 23.2 | 25 | 12 | 12 | 2 | 12 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.78 |
| RP | Britton, Z.Britton, Zach † >> | 28 | 2016 | L | 78 | 104 | 0 | 5 | 1 | 1.49 | .232 | 0.89 | 4.8 | 3.3 | 7.2 | 66.1 | 35 | 13 | 11 | 3 | 24 | 53 | 0 | 7 | 4 | 0 | 0 | 1 | 3 | 3.12 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 65 | 3 | 0 | 0 | 0 | 0.00 | .091 | 0.30 | 3.0 | 0.0 | 9.0 | 3.1 | 1 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |