| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 35 | 35 | 17 | 13 | 3.45 | .290 | 1.20 | 8.5 | 2.3 | 7.2 | 255.1 | 241 | 111 | 98 | 19 | 66 | 205 | 5 | 0 | 0 | 1 | 23 | 6 | 7 | 3.21 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 34 | 34 | 18 | 9 | 3.88 | .300 | 1.26 | 8.1 | 3.3 | 7.7 | 194.2 | 174 | 87 | 84 | 20 | 71 | 166 | 0 | 0 | 0 | 0 | 15 | 5 | 5 | 3.80 |
| SP | Reulbach, E.Reulbach, Ed † $$ >> | 24 | 1906 | R | 61 | 33 | 33 | 18 | 9 | 2.68 | .297 | 1.23 | 7.1 | 4.0 | 3.7 | 228.0 | 179 | 78 | 68 | 16 | 102 | 94 | 3 | 0 | 0 | 1 | 26 | 8 | 3 | 4.54 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 33 | 33 | 13 | 8 | 4.30 | .304 | 1.28 | 7.9 | 3.7 | 3.5 | 184.1 | 161 | 92 | 88 | 15 | 75 | 71 | 0 | 0 | 0 | 0 | 16 | 6 | 3 | 4.61 |
| SP | Blue, V.Blue, Vida † # >> | 22 | 1971 | L | 79 | 31 | 31 | 14 | 7 | 4.41 | .302 | 1.29 | 8.9 | 2.7 | 7.2 | 200.0 | 197 | 102 | 98 | 25 | 60 | 160 | 4 | 0 | 0 | 0 | 15 | 2 | 2 | 3.96 |
| RP | Chapman, A.Chapman, Aroldis $ >> | 26 | 2014 | L | 92 | 95 | 0 | 9 | 1 | 3.02 | .271 | 1.08 | 5.1 | 4.7 | 10.0 | 83.1 | 47 | 29 | 28 | 7 | 43 | 92 | 0 | 3 | 1 | 0 | 0 | 3 | 5 | 3.54 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 99 | 0 | 4 | 2 | 2.85 | .272 | 1.11 | 6.1 | 3.8 | 9.5 | 82.0 | 56 | 29 | 26 | 6 | 35 | 87 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.15 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 50 | 0 | 1 | 3 | 3.14 | .246 | 0.95 | 5.4 | 3.1 | 8.4 | 43.0 | 26 | 15 | 15 | 3 | 15 | 40 | 0 | 8 | 3 | 0 | 0 | 1 | 6 | 3.16 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 75 | 0 | 2 | 2 | 3.24 | .286 | 1.14 | 5.4 | 4.9 | 11.7 | 50.0 | 30 | 18 | 18 | 6 | 27 | 65 | 0 | 6 | 5 | 0 | 0 | 3 | 1 | 3.76 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 51 | 0 | 3 | 2 | 3.51 | .291 | 1.23 | 6.0 | 5.3 | 6.4 | 48.2 | 32 | 19 | 19 | 1 | 28 | 34 | 0 | 7 | 2 | 0 | 0 | 0 | 2 | 3.60 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 33 | 46 | 0 | 2 | 0 | 4.08 | .323 | 1.43 | 7.3 | 5.6 | 8.7 | 53.0 | 43 | 24 | 24 | 5 | 33 | 51 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 4.17 |