| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 22 | 22 | 7 | 7 | 3.54 | .264 | 1.07 | 7.8 | 1.8 | 8.3 | 152.2 | 132 | 64 | 60 | 16 | 31 | 140 | 3 | 0 | 0 | 0 | 15 | 1 | 1 | 3.16 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 21 | 21 | 10 | 7 | 4.37 | .317 | 1.37 | 9.9 | 2.5 | 7.8 | 131.2 | 144 | 66 | 64 | 20 | 37 | 114 | 0 | 0 | 0 | 0 | 10 | 2 | 5 | 4.14 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 20 | 20 | 8 | 4 | 4.08 | .301 | 1.25 | 8.4 | 2.8 | 8.5 | 130.0 | 122 | 64 | 59 | 15 | 41 | 123 | 0 | 0 | 0 | 0 | 13 | 5 | 2 | 3.67 |
| SP | Lundgren, C.Lundgren, Carl † >> | 27 | 1907 | R | 43 | 20 | 20 | 13 | 3 | 3.41 | .297 | 1.25 | 6.3 | 4.9 | 4.2 | 142.1 | 100 | 56 | 54 | 11 | 78 | 66 | 3 | 0 | 0 | 0 | 13 | 2 | 3 | 4.77 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 55 | 0 | 6 | 4 | 2.97 | .297 | 1.26 | 7.2 | 4.2 | 9.4 | 75.2 | 60 | 26 | 25 | 8 | 35 | 78 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.75 |
| CL | Miller, A.Miller, Andrew † >> | 31 | 2016 | L | 92 | 46 | 0 | 3 | 3 | 2.74 | .242 | 0.93 | 5.5 | 2.9 | 9.0 | 46.0 | 28 | 14 | 14 | 4 | 15 | 46 | 0 | 27 | 4 | 0 | 0 | 1 | 0 | 3.17 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 27 | 0 | 2 | 2 | 1.48 | .235 | 0.92 | 5.7 | 2.7 | 8.7 | 30.1 | 19 | 5 | 5 | 2 | 9 | 29 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.83 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 20 | 0 | 1 | 0 | 1.16 | .271 | 1.11 | 5.1 | 5.1 | 5.9 | 23.1 | 13 | 3 | 3 | 1 | 13 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.96 |