| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 38 | 38 | 19 | 9 | 2.88 | .285 | 1.18 | 7.5 | 3.1 | 9.1 | 259.2 | 216 | 88 | 83 | 22 | 90 | 263 | 4 | 0 | 0 | 0 | 29 | 4 | 2 | 3.16 |
| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 37 | 37 | 15 | 10 | 3.95 | .279 | 1.13 | 8.0 | 2.2 | 5.1 | 252.2 | 224 | 117 | 111 | 28 | 61 | 144 | 12 | 0 | 0 | 5 | 17 | 9 | 3 | 4.13 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 35 | 35 | 13 | 16 | 5.33 | .317 | 1.36 | 9.3 | 2.9 | 8.0 | 211.0 | 217 | 132 | 125 | 38 | 69 | 188 | 5 | 0 | 0 | 0 | 13 | 8 | 4 | 4.65 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 77 | 33 | 33 | 13 | 9 | 4.61 | .311 | 1.32 | 7.9 | 4.0 | 7.7 | 185.2 | 162 | 99 | 95 | 21 | 83 | 159 | 0 | 0 | 0 | 0 | 14 | 6 | 0 | 4.20 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 95 | 0 | 6 | 2 | 3.65 | .286 | 1.20 | 7.9 | 3.0 | 8.2 | 128.1 | 112 | 55 | 52 | 8 | 42 | 117 | 0 | 11 | 6 | 0 | 0 | 0 | 2 | 2.97 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 92 | 87 | 0 | 9 | 5 | 2.49 | .249 | 0.97 | 6.7 | 2.0 | 7.7 | 115.2 | 86 | 34 | 32 | 13 | 26 | 98 | 0 | 9 | 3 | 0 | 0 | 3 | 0 | 3.52 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 40 | 0 | 0 | 2 | 4.68 | .335 | 1.44 | 7.7 | 5.4 | 9.2 | 42.1 | 36 | 22 | 22 | 9 | 25 | 43 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 5.74 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 37 | 0 | 3 | 1 | 2.35 | .303 | 1.30 | 6.9 | 5.0 | 9.0 | 38.1 | 29 | 12 | 10 | 4 | 21 | 38 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 4.03 |