| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 36 | 36 | 12 | 12 | 4.66 | .302 | 1.27 | 9.0 | 2.5 | 7.9 | 203.0 | 202 | 116 | 105 | 33 | 56 | 179 | 0 | 0 | 0 | 0 | 19 | 5 | 0 | 4.25 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 13 | 11 | 4.26 | .339 | 1.52 | 9.0 | 4.7 | 8.7 | 196.2 | 197 | 98 | 93 | 24 | 102 | 190 | 1 | 0 | 0 | 0 | 19 | 4 | 7 | 4.28 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 66 | 0 | 5 | 3 | 2.73 | .275 | 1.11 | 6.8 | 3.3 | 8.7 | 69.1 | 52 | 22 | 21 | 4 | 25 | 67 | 0 | 32 | 4 | 0 | 0 | 2 | 3 | 2.99 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 69 | 0 | 1 | 2 | 3.57 | .302 | 1.28 | 7.8 | 3.8 | 10.0 | 75.2 | 65 | 30 | 30 | 8 | 32 | 83 | 0 | 3 | 4 | 0 | 0 | 1 | 0 | 3.49 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 88 | 0 | 6 | 4 | 4.00 | .318 | 1.37 | 8.1 | 4.4 | 6.4 | 105.2 | 94 | 47 | 47 | 13 | 51 | 75 | 0 | 2 | 3 | 0 | 0 | 3 | 0 | 4.72 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 78 | 0 | 7 | 4 | 4.29 | .340 | 1.52 | 8.0 | 5.8 | 9.2 | 86.0 | 76 | 42 | 41 | 12 | 55 | 88 | 0 | 0 | 3 | 0 | 0 | 2 | 1 | 4.76 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 69 | 0 | 3 | 3 | 2.49 | .264 | 1.05 | 6.6 | 3.0 | 7.7 | 97.2 | 71 | 30 | 27 | 12 | 32 | 83 | 0 | 2 | 0 | 0 | 0 | 2 | 3 | 3.95 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 70 | 1 | 0 | 0 | 0 | 0.00 | .500 | 3.00 | - | - | - | 0.1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 26 | 0 | 1 | 4 | 5.43 | .327 | 1.43 | 10.1 | 2.8 | 5.6 | 127.2 | 143 | 80 | 77 | 16 | 40 | 79 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 4.41 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 16 | 0 | 1 | 2 | 4.20 | .297 | 1.27 | 7.8 | 3.6 | 5.7 | 30.0 | 26 | 14 | 14 | 5 | 12 | 19 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.10 |