| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 34 | 34 | 15 | 12 | 3.36 | .294 | 1.23 | 7.8 | 3.3 | 8.4 | 265.1 | 229 | 114 | 99 | 18 | 97 | 247 | 10 | 0 | 0 | 3 | 19 | 5 | 10 | 3.17 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 79 | 33 | 33 | 10 | 15 | 4.75 | .322 | 1.39 | 9.3 | 3.2 | 8.7 | 218.0 | 225 | 129 | 115 | 28 | 78 | 211 | 2 | 0 | 0 | 0 | 18 | 7 | 6 | 3.90 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 32 | 32 | 9 | 18 | 4.50 | .324 | 1.41 | 9.3 | 3.4 | 5.7 | 220.0 | 227 | 121 | 110 | 34 | 83 | 140 | 8 | 0 | 0 | 0 | 15 | 6 | 5 | 4.95 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 32 | 32 | 9 | 17 | 4.97 | .341 | 1.54 | 10.3 | 3.6 | 5.4 | 215.1 | 247 | 138 | 119 | 25 | 85 | 128 | 8 | 0 | 0 | 0 | 12 | 2 | 5 | 4.53 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 79 | 0 | 7 | 8 | 4.07 | .281 | 1.16 | 8.1 | 2.4 | 8.9 | 97.1 | 87 | 50 | 44 | 14 | 26 | 96 | 0 | 11 | 4 | 0 | 0 | 1 | 1 | 3.73 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 77 | 60 | 0 | 2 | 3 | 4.31 | .336 | 1.52 | 9.0 | 4.8 | 7.7 | 64.2 | 64 | 31 | 31 | 10 | 34 | 55 | 0 | 6 | 5 | 0 | 0 | 0 | 5 | 4.91 |
| RP | Harvey, B.Harvey, Bryan # >> | 28 | 1991 | R | 67 | 38 | 0 | 2 | 3 | 3.80 | .297 | 1.24 | 8.6 | 2.6 | 7.6 | 45.0 | 43 | 21 | 19 | 6 | 13 | 38 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 3.98 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 59 | 34 | 0 | 2 | 1 | 3.71 | .316 | 1.37 | 7.6 | 4.8 | 6.3 | 53.1 | 45 | 23 | 22 | 8 | 28 | 37 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 5.21 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 65 | 11 | 0 | 1 | 1 | 3.91 | .324 | 1.43 | 10.2 | 2.7 | 2.0 | 23.0 | 26 | 12 | 10 | 0 | 7 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.48 |