| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 14 | 16 | 3.81 | .283 | 1.17 | 8.4 | 2.1 | 7.8 | 255.0 | 239 | 115 | 108 | 27 | 59 | 220 | 10 | 0 | 0 | 2 | 20 | 4 | 3 | 3.39 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 33 | 33 | 11 | 13 | 4.11 | .280 | 1.15 | 7.6 | 2.8 | 8.4 | 238.2 | 201 | 116 | 109 | 33 | 74 | 223 | 5 | 0 | 0 | 1 | 19 | 4 | 4 | 3.91 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 31 | 31 | 12 | 16 | 4.83 | .326 | 1.43 | 9.5 | 3.4 | 4.2 | 225.2 | 238 | 137 | 121 | 21 | 84 | 104 | 13 | 0 | 0 | 3 | 15 | 6 | 5 | 4.49 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 77 | 0 | 3 | 6 | 3.86 | .326 | 1.43 | 8.3 | 4.6 | 11.1 | 95.2 | 88 | 41 | 41 | 7 | 49 | 117 | 0 | 9 | 5 | 0 | 0 | 2 | 9 | 3.11 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 89 | 66 | 0 | 6 | 6 | 2.90 | .260 | 1.04 | 8.0 | 1.4 | 9.0 | 71.1 | 63 | 23 | 23 | 7 | 11 | 71 | 0 | 11 | 3 | 0 | 0 | 1 | 0 | 2.79 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 70 | 45 | 0 | 2 | 5 | 3.03 | .255 | 1.03 | 7.0 | 2.3 | 5.1 | 62.1 | 48 | 23 | 21 | 14 | 16 | 35 | 0 | 8 | 1 | 0 | 0 | 0 | 3 | 5.58 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 64 | 18 | 0 | 3 | 1 | 2.08 | .316 | 1.38 | 7.3 | 5.6 | 11.1 | 21.2 | 17 | 8 | 5 | 2 | 13 | 26 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.62 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 58 | 25 | 0 | 0 | 0 | 3.72 | .256 | 1.03 | 6.5 | 2.8 | 8.7 | 29.0 | 21 | 12 | 12 | 4 | 9 | 28 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.79 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 6 | 2 | 1 | 1 | 5.09 | .376 | 1.81 | 11.6 | 5.3 | 3.2 | 17.2 | 22 | 12 | 10 | 1 | 10 | 6 | 0 | 1 | 0 | 0 | 1 | 0 | 2 | 4.82 |