| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 93 | 35 | 35 | 17 | 12 | 2.92 | .260 | 1.04 | 6.7 | 2.6 | 4.9 | 271.2 | 203 | 90 | 88 | 15 | 79 | 149 | 6 | 0 | 0 | 1 | 23 | 5 | 8 | 3.55 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 93 | 34 | 34 | 17 | 10 | 3.41 | .259 | 1.01 | 7.2 | 1.9 | 6.8 | 248.0 | 199 | 101 | 94 | 20 | 52 | 188 | 6 | 0 | 0 | 1 | 23 | 9 | 7 | 3.27 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 73 | 0 | 1 | 4 | 3.60 | .261 | 1.04 | 6.7 | 2.7 | 9.4 | 70.0 | 52 | 30 | 28 | 11 | 21 | 73 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.90 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 45 | 0 | 2 | 1 | 1.64 | .237 | 0.89 | 5.9 | 2.2 | 9.2 | 49.1 | 32 | 9 | 9 | 3 | 12 | 50 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 2.61 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 80 | 34 | 0 | 7 | 0 | 1.96 | .262 | 1.04 | 6.0 | 3.5 | 3.5 | 36.2 | 24 | 8 | 8 | 1 | 14 | 14 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.83 |
| RP | Arroyo, L.Arroyo, Luis >> | 34 | 1961 | L | 14 | 74 | 0 | 1 | 3 | 3.31 | .305 | 1.32 | 8.0 | 4.0 | 4.4 | 70.2 | 62 | 28 | 26 | 8 | 31 | 34 | 0 | 3 | 2 | 0 | 0 | 0 | 5 | 4.84 |
| SP | Bender, C.Bender, Chief † >> | 26 | 1910 | R | 72 | 33 | 32 | 15 | 16 | 3.69 | .290 | 1.20 | 7.7 | 3.1 | 4.8 | 241.2 | 207 | 106 | 99 | 23 | 84 | 129 | 11 | 1 | 0 | 3 | 19 | 5 | 3 | 4.28 |
| SP | Hubbell, C.Hubbell, Carl >> | 30 | 1933 | L | 37 | 6 | 3 | 3 | 2 | 1.76 | .207 | 0.78 | 5.4 | 1.8 | 5.4 | 30.2 | 18 | 6 | 6 | 1 | 6 | 18 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 2.83 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 62 | 0 | 2 | 5 | 4.27 | .309 | 1.29 | 8.2 | 3.4 | 7.9 | 59.0 | 54 | 29 | 28 | 10 | 22 | 52 | 0 | 40 | 9 | 0 | 0 | 3 | 2 | 4.71 |