| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 10 | 10 | 5 | 5 | 4.08 | .300 | 1.23 | 8.3 | 2.8 | 5.7 | 68.1 | 63 | 32 | 31 | 7 | 21 | 43 | 2 | 0 | 0 | 0 | 6 | 4 | 2 | 4.18 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 10 | 9 | 7 | 2 | 2.33 | .263 | 1.03 | 7.2 | 2.1 | 4.6 | 77.1 | 62 | 22 | 20 | 6 | 18 | 39 | 5 | 1 | 0 | 1 | 8 | 3 | 1 | 3.82 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 20 | 0 | 0 | 0 | 2.89 | .253 | 1.02 | 7.0 | 2.5 | 8.5 | 18.2 | 14 | 6 | 6 | 3 | 5 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.11 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 10 | 0 | 1 | 0 | 1.80 | .318 | 1.30 | 7.2 | 4.5 | 7.2 | 10.0 | 8 | 2 | 2 | 1 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.50 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 7 | 0 | 0 | 0 | 0.93 | .194 | 0.72 | 3.0 | 4.0 | 6.0 | 9.2 | 3 | 1 | 1 | 0 | 4 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Arroyo, L.Arroyo, Luis >> | 34 | 1961 | L | 13 | 21 | 0 | 0 | 2 | 4.15 | .278 | 1.15 | 6.0 | 4.7 | 4.3 | 21.2 | 14 | 10 | 10 | 4 | 11 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6.10 |
| SP | Hubbell, C.Hubbell, Carl >> | 30 | 1933 | L | 37 | 2 | 1 | 1 | 0 | 0.87 | .088 | 0.29 | 2.7 | 0.0 | 5.4 | 10.1 | 3 | 1 | 1 | 1 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3.10 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 16 | 0 | 1 | 1 | 3.12 | .316 | 1.33 | 6.9 | 5.3 | 6.9 | 17.1 | 13 | 6 | 6 | 2 | 10 | 13 | 0 | 8 | 2 | 0 | 0 | 1 | 2 | 4.94 |