| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 22 | 22 | 11 | 5 | 2.60 | .276 | 1.11 | 7.3 | 2.7 | 8.9 | 145.1 | 118 | 45 | 42 | 13 | 43 | 144 | 0 | 0 | 0 | 0 | 15 | 5 | 0 | 3.17 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 21 | 21 | 9 | 8 | 4.77 | .308 | 1.33 | 9.4 | 2.7 | 9.1 | 122.2 | 127 | 66 | 65 | 18 | 36 | 123 | 0 | 0 | 0 | 0 | 13 | 1 | 1 | 3.81 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 20 | 20 | 4 | 9 | 6.68 | .382 | 1.82 | 10.7 | 5.7 | 4.3 | 98.1 | 117 | 77 | 73 | 22 | 62 | 47 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 6.95 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 61 | 0 | 0 | 0 | 2.81 | .273 | 1.11 | 5.6 | 4.4 | 8.6 | 67.1 | 42 | 27 | 21 | 9 | 33 | 64 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 4.36 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 61 | 0 | 6 | 5 | 5.19 | .342 | 1.53 | 9.2 | 4.6 | 10.2 | 59.0 | 60 | 34 | 34 | 11 | 30 | 67 | 0 | 1 | 2 | 0 | 0 | 2 | 6 | 4.78 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 42 | 0 | 3 | 4 | 7.06 | .332 | 1.47 | 10.2 | 3.0 | 7.9 | 51.0 | 58 | 43 | 40 | 12 | 17 | 45 | 0 | 2 | 0 | 0 | 0 | 1 | 5 | 5.35 |