| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 12 | 12 | 4 | 5 | 4.09 | .321 | 1.38 | 9.5 | 2.9 | 7.7 | 77.0 | 81 | 37 | 35 | 5 | 25 | 66 | 0 | 0 | 0 | 0 | 7 | 3 | 1 | 3.22 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 12 | 12 | 2 | 4 | 5.00 | .326 | 1.43 | 9.7 | 3.3 | 8.1 | 68.1 | 73 | 39 | 38 | 11 | 25 | 61 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 4.46 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 12 | 12 | 5 | 0 | 3.82 | .281 | 1.15 | 7.5 | 3.0 | 5.7 | 70.2 | 58 | 34 | 30 | 8 | 23 | 44 | 1 | 0 | 0 | 0 | 8 | 2 | 0 | 4.30 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 22 | 0 | 4 | 2 | 2.05 | .258 | 0.98 | 7.2 | 1.8 | 10.2 | 30.2 | 24 | 8 | 7 | 4 | 6 | 34 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 3.27 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 86 | 17 | 0 | 1 | 0 | 2.00 | .229 | 0.85 | 5.7 | 2.0 | 9.0 | 27.0 | 17 | 6 | 6 | 3 | 6 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.22 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 16 | 0 | 0 | 2 | 3.98 | .256 | 1.03 | 6.8 | 2.7 | 7.7 | 20.1 | 15 | 10 | 9 | 5 | 6 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.45 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 13 | 0 | 1 | 0 | 2.81 | .304 | 1.31 | 6.8 | 5.1 | 9.6 | 16.0 | 12 | 5 | 5 | 1 | 9 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.38 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 17 | 0 | 2 | 3 | 3.68 | .267 | 1.09 | 6.1 | 3.7 | 5.7 | 22.0 | 15 | 9 | 9 | 3 | 9 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.73 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 4 | 0 | 0 | 1 | 2.57 | .300 | 1.29 | 11.6 | 0.0 | 9.0 | 7.0 | 9 | 6 | 2 | 2 | 0 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.71 |