| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 33 | 33 | 11 | 14 | 3.44 | .274 | 1.11 | 8.5 | 1.6 | 7.6 | 262.0 | 246 | 104 | 100 | 27 | 46 | 220 | 10 | 0 | 0 | 2 | 21 | 5 | 6 | 3.24 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 33 | 33 | 12 | 8 | 4.86 | .303 | 1.29 | 8.7 | 2.9 | 5.2 | 181.2 | 175 | 102 | 98 | 23 | 59 | 104 | 0 | 0 | 0 | 0 | 10 | 3 | 2 | 4.53 |
| SP | Pfiester, J.Pfiester, Jack † # >> | 28 | 1906 | L | 74 | 32 | 32 | 17 | 10 | 3.54 | .268 | 1.09 | 7.8 | 2.1 | 4.5 | 264.1 | 228 | 107 | 104 | 26 | 61 | 132 | 14 | 0 | 0 | 1 | 20 | 1 | 3 | 3.98 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 32 | 32 | 12 | 17 | 5.40 | .331 | 1.45 | 10.4 | 2.7 | 4.3 | 226.2 | 260 | 150 | 136 | 28 | 69 | 108 | 6 | 0 | 0 | 0 | 12 | 7 | 6 | 4.66 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 31 | 31 | 14 | 13 | 4.47 | .338 | 1.52 | 8.9 | 4.8 | 4.5 | 209.1 | 206 | 107 | 104 | 17 | 112 | 104 | 1 | 0 | 0 | 0 | 18 | 2 | 4 | 4.70 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 85 | 0 | 5 | 4 | 2.55 | .289 | 1.20 | 6.4 | 4.5 | 8.2 | 113.0 | 80 | 33 | 32 | 7 | 56 | 103 | 0 | 10 | 6 | 0 | 0 | 2 | 3 | 3.52 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 66 | 0 | 7 | 3 | 3.13 | .249 | 0.96 | 7.2 | 1.5 | 6.9 | 83.1 | 66 | 33 | 29 | 10 | 14 | 64 | 0 | 9 | 2 | 0 | 0 | 3 | 0 | 3.64 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 61 | 41 | 0 | 2 | 3 | 1.64 | .283 | 1.16 | 7.2 | 3.3 | 4.3 | 44.0 | 35 | 10 | 8 | 3 | 16 | 21 | 0 | 6 | 2 | 0 | 0 | 1 | 2 | 4.09 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 23 | 0 | 1 | 3 | 4.07 | .298 | 1.27 | 6.4 | 5.3 | 7.9 | 24.1 | 17 | 14 | 11 | 2 | 14 | 21 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 4.08 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 46 | 4 | 0 | 2 | 0 | 2.45 | .371 | 1.77 | 14.1 | 2.6 | 11.6 | 7.1 | 11 | 4 | 2 | 1 | 2 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.14 |