| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 33 | 33 | 17 | 12 | 3.84 | .301 | 1.27 | 8.8 | 2.7 | 8.6 | 241.2 | 235 | 117 | 103 | 34 | 72 | 229 | 6 | 0 | 0 | 1 | 19 | 5 | 5 | 3.89 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 32 | 32 | 11 | 16 | 5.67 | .343 | 1.53 | 10.3 | 3.6 | 7.4 | 204.2 | 233 | 139 | 129 | 23 | 81 | 168 | 3 | 0 | 0 | 0 | 13 | 6 | 11 | 4.10 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 32 | 32 | 19 | 8 | 3.83 | .286 | 1.18 | 8.5 | 2.2 | 5.3 | 251.2 | 236 | 114 | 107 | 27 | 62 | 148 | 16 | 0 | 0 | 1 | 18 | 4 | 1 | 4.01 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 77 | 0 | 7 | 1 | 1.51 | .235 | 0.88 | 4.7 | 3.2 | 8.3 | 95.2 | 50 | 21 | 16 | 4 | 34 | 88 | 0 | 9 | 1 | 0 | 0 | 4 | 0 | 2.89 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 58 | 0 | 2 | 7 | 4.12 | .325 | 1.43 | 9.5 | 3.5 | 8.8 | 54.2 | 57 | 29 | 25 | 6 | 21 | 53 | 0 | 7 | 3 | 0 | 0 | 1 | 0 | 3.70 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 12 | 0 | 1 | 1 | 5.25 | .368 | 1.75 | 11.3 | 4.5 | 8.3 | 12.0 | 15 | 7 | 7 | 0 | 6 | 11 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 2.67 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 4 | 0 | 0 | 1 | 3.86 | .222 | 0.86 | 9.0 | 0.0 | 4.5 | 4.2 | 4 | 2 | 2 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 17 | 0 | 0 | 0 | 2.86 | .250 | 1.00 | 7.0 | 2.0 | 6.5 | 22.0 | 17 | 8 | 7 | 2 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.41 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 14 | 0 | 4 | 0 | 3.84 | .320 | 1.41 | 9.3 | 3.4 | 4.5 | 68.0 | 70 | 36 | 29 | 5 | 26 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.10 |