| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 32 | 32 | 15 | 9 | 3.75 | .297 | 1.24 | 8.2 | 3.0 | 4.1 | 211.0 | 192 | 95 | 88 | 18 | 70 | 95 | 0 | 0 | 0 | 0 | 17 | 5 | 3 | 4.27 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 32 | 32 | 14 | 10 | 3.70 | .303 | 1.28 | 7.7 | 3.8 | 8.2 | 214.1 | 184 | 94 | 88 | 17 | 90 | 194 | 3 | 0 | 0 | 2 | 19 | 5 | 5 | 3.55 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 32 | 32 | 19 | 10 | 2.79 | .259 | 1.03 | 7.1 | 2.2 | 5.2 | 261.2 | 206 | 83 | 81 | 21 | 63 | 150 | 17 | 0 | 0 | 3 | 22 | 6 | 4 | 3.69 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 32 | 32 | 15 | 13 | 4.03 | .298 | 1.25 | 8.9 | 2.4 | 3.7 | 225.2 | 222 | 106 | 101 | 33 | 59 | 93 | 3 | 0 | 0 | 0 | 20 | 6 | 3 | 4.95 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 47 | 28 | 28 | 11 | 10 | 3.79 | .296 | 1.25 | 7.2 | 4.0 | 7.6 | 190.0 | 152 | 85 | 80 | 14 | 85 | 161 | 1 | 0 | 0 | 1 | 16 | 3 | 6 | 3.65 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 88 | 0 | 2 | 5 | 2.22 | .249 | 0.99 | 5.1 | 3.8 | 8.4 | 125.2 | 71 | 33 | 31 | 9 | 53 | 117 | 0 | 21 | 5 | 0 | 0 | 1 | 0 | 3.36 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 49 | 0 | 6 | 1 | 4.04 | .316 | 1.37 | 8.8 | 3.5 | 7.7 | 49.0 | 48 | 22 | 22 | 8 | 19 | 42 | 0 | 8 | 2 | 0 | 0 | 1 | 2 | 4.63 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 22 | 0 | 3 | 3 | 3.33 | .289 | 1.15 | 6.3 | 4.0 | 5.0 | 27.0 | 19 | 10 | 10 | 1 | 12 | 15 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 3.93 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 44 | 15 | 0 | 3 | 1 | 4.80 | .328 | 1.47 | 8.4 | 4.8 | 7.8 | 15.0 | 14 | 9 | 8 | 1 | 8 | 13 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.73 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 24 | 0 | 0 | 0 | 4.30 | .310 | 1.35 | 9.4 | 2.7 | 8.2 | 23.0 | 24 | 12 | 11 | 4 | 7 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.35 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 18 | 3 | 5 | 4 | 4.50 | .305 | 1.25 | 8.1 | 3.1 | 5.6 | 92.0 | 83 | 47 | 46 | 13 | 32 | 57 | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 4.84 |