| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 100 | 17 | 17 | 7 | 5 | 3.21 | .262 | 1.05 | 7.1 | 2.4 | 9.2 | 112.0 | 88 | 44 | 40 | 13 | 30 | 114 | 3 | 0 | 0 | 1 | 10 | 1 | 1 | 3.30 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 92 | 16 | 16 | 7 | 5 | 4.23 | .291 | 1.21 | 7.4 | 3.5 | 8.0 | 100.0 | 82 | 54 | 47 | 16 | 39 | 89 | 1 | 0 | 0 | 1 | 8 | 2 | 4 | 4.53 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 16 | 16 | 9 | 4 | 3.03 | .313 | 1.37 | 9.3 | 2.9 | 8.4 | 104.0 | 108 | 37 | 35 | 11 | 34 | 97 | 0 | 0 | 0 | 0 | 12 | 0 | 1 | 3.49 |
| SP | McKenzie, T.McKenzie, Triston >> | 24 | 2022 | R | 78 | 16 | 16 | 5 | 6 | 4.86 | .298 | 1.24 | 7.7 | 3.5 | 7.0 | 83.1 | 71 | 48 | 45 | 13 | 32 | 65 | 1 | 0 | 0 | 1 | 8 | 3 | 5 | 4.73 |
| RP | Miller, A.Miller, Andrew >> | 32 | 2017 | L | 96 | 44 | 0 | 2 | 0 | 2.16 | .242 | 0.91 | 5.0 | 3.3 | 8.8 | 41.2 | 23 | 10 | 10 | 6 | 15 | 40 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 4.20 |
| RP | Clase, E.Clase, Emmanuel >> | 24 | 2022 | R | 93 | 49 | 0 | 0 | 1 | 2.72 | .268 | 1.06 | 6.7 | 2.9 | 9.0 | 46.1 | 34 | 14 | 14 | 3 | 15 | 46 | 0 | 2 | 1 | 0 | 0 | 2 | 2 | 2.96 |
| RP | Madson, R.Madson, Ryan >> | 37 | 2017 | R | 87 | 41 | 0 | 2 | 1 | 2.25 | .250 | 1.00 | 6.5 | 2.5 | 10.6 | 40.0 | 29 | 11 | 10 | 2 | 11 | 47 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 2.13 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 85 | 33 | 0 | 4 | 2 | 2.10 | .254 | 0.99 | 6.9 | 2.1 | 9.0 | 34.1 | 26 | 8 | 8 | 4 | 8 | 34 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.32 |
| RP | Doolittle, S.Doolittle, Sean >> | 30 | 2017 | L | 80 | 43 | 0 | 0 | 1 | 3.04 | .252 | 1.01 | 6.6 | 2.8 | 9.3 | 26.2 | 19 | 9 | 9 | 6 | 8 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.85 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 71 | 25 | 0 | 0 | 2 | 5.56 | .327 | 1.46 | 7.8 | 5.7 | 11.9 | 22.2 | 19 | 14 | 14 | 3 | 14 | 29 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 4.05 |
| RP | Osuna, R.Osuna, Roberto >> | 24 | 2019 | R | 72 | 22 | 0 | 2 | 3 | 4.70 | .216 | 0.83 | 6.3 | 1.2 | 11.3 | 23.0 | 16 | 12 | 12 | 5 | 3 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.70 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 57 | 6 | 0 | 1 | 0 | 3.86 | .333 | 1.50 | 13.5 | 2.3 | 9.0 | 4.2 | 6 | 3 | 2 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |