| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 61 | 17 | 17 | 6 | 3 | 3.80 | .273 | 1.13 | 6.9 | 3.3 | 6.4 | 113.2 | 87 | 49 | 48 | 16 | 41 | 80 | 0 | 0 | 0 | 0 | 9 | 0 | 4 | 4.51 |
| SP | Santana, J.Santana, Johan >> | 27 | 2006 | L | 47 | 17 | 17 | 5 | 7 | 4.31 | .285 | 1.16 | 7.7 | 2.7 | 8.4 | 119.0 | 102 | 58 | 57 | 21 | 36 | 111 | 1 | 0 | 0 | 1 | 10 | 4 | 1 | 4.44 |
| SP | Liriano, F.Liriano, Francisco # >> | 23 | 2006 | L | 64 | 17 | 17 | 4 | 7 | 5.04 | .310 | 1.32 | 9.2 | 2.6 | 8.5 | 75.0 | 77 | 43 | 42 | 15 | 22 | 71 | 0 | 0 | 0 | 0 | 2 | 2 | 3 | 4.67 |
| SP | Lester, J.Lester, Jon # >> | 32 | 2016 | L | 46 | 17 | 17 | 8 | 5 | 4.79 | .308 | 1.32 | 9.2 | 2.7 | 6.0 | 107.0 | 109 | 59 | 57 | 18 | 32 | 71 | 0 | 0 | 0 | 0 | 9 | 2 | 1 | 4.81 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 40 | 16 | 16 | 8 | 5 | 3.16 | .297 | 1.25 | 6.6 | 4.6 | 5.7 | 111.0 | 82 | 44 | 39 | 10 | 57 | 70 | 0 | 0 | 0 | 0 | 10 | 2 | 4 | 4.50 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 50 | 0 | 4 | 2 | 2.63 | .297 | 1.25 | 7.2 | 4.1 | 8.7 | 61.2 | 49 | 18 | 18 | 5 | 28 | 59 | 0 | 0 | 2 | 0 | 0 | 1 | 4 | 3.56 |
| RP | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 92 | 39 | 0 | 4 | 0 | 2.45 | .270 | 1.11 | 7.3 | 2.9 | 8.8 | 47.2 | 38 | 13 | 13 | 2 | 15 | 46 | 0 | 0 | 5 | 0 | 0 | 0 | 6 | 2.55 |
| RP | Reyes, D.Reyes, Dennys >> | 29 | 2006 | L | 56 | 17 | 0 | 2 | 0 | 6.91 | .386 | 1.88 | 13.5 | 3.9 | 7.1 | 14.1 | 21 | 11 | 11 | 1 | 6 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.64 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 48 | 22 | 0 | 1 | 1 | 4.32 | .318 | 1.40 | 9.7 | 2.9 | 5.8 | 25.0 | 27 | 12 | 12 | 2 | 8 | 16 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.72 |