| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 18 | 18 | 7 | 11 | 3.73 | .282 | 1.17 | 8.1 | 2.4 | 9.9 | 115.2 | 104 | 53 | 48 | 16 | 31 | 127 | 1 | 0 | 0 | 0 | 13 | 1 | 0 | 3.43 |
| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 18 | 18 | 10 | 7 | 3.61 | .263 | 1.06 | 7.0 | 2.6 | 10.3 | 127.0 | 99 | 51 | 51 | 12 | 36 | 146 | 4 | 0 | 0 | 2 | 11 | 1 | 2 | 2.80 |
| SP | Greinke, Z.Greinke, Zack >> | 36 | 2019 | R | 50 | 18 | 17 | 8 | 6 | 5.13 | .312 | 1.35 | 10.3 | 1.9 | 6.2 | 98.1 | 112 | 57 | 56 | 17 | 21 | 67 | 1 | 0 | 0 | 1 | 9 | 1 | 0 | 4.56 |
| RP | Osuna, R.Osuna, Roberto >> | 24 | 2019 | R | 76 | 48 | 0 | 1 | 0 | 2.32 | .276 | 1.12 | 6.8 | 3.3 | 8.7 | 54.1 | 41 | 14 | 14 | 3 | 20 | 52 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 2.96 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 77 | 39 | 0 | 1 | 1 | 2.68 | .258 | 1.02 | 6.3 | 2.9 | 9.9 | 40.1 | 28 | 13 | 12 | 4 | 13 | 44 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 3.15 |
| RP | Harris, W.Harris, Will >> | 34 | 2019 | R | 69 | 27 | 0 | 1 | 2 | 7.06 | .356 | 1.66 | 12.9 | 2.6 | 9.9 | 21.2 | 30 | 19 | 17 | 5 | 6 | 23 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.76 |
| RP | Hoerner, J.Hoerner, Joe >> | 32 | 1968 | L | 65 | 28 | 0 | 1 | 2 | 5.09 | .349 | 1.61 | 11.0 | 3.5 | 7.0 | 23.0 | 28 | 16 | 13 | 3 | 9 | 18 | 0 | 5 | 1 | 0 | 0 | 0 | 2 | 4.30 |