| SP | Messersmith, A.Messersmith, Andy >> | 29 | 1974 | R | 94 | 33 | 33 | 18 | 10 | 2.70 | .266 | 1.07 | 6.7 | 3.0 | 6.0 | 253.1 | 187 | 82 | 76 | 19 | 84 | 170 | 15 | 0 | 0 | 5 | 24 | 4 | 5 | 3.68 |
| SP | Rasmussen, D.Rasmussen, Dennis >> | 17 | 1986 | L | 87 | 33 | 33 | 14 | 13 | 4.10 | .287 | 1.18 | 7.4 | 3.3 | 4.9 | 215.1 | 176 | 106 | 98 | 22 | 78 | 118 | 3 | 0 | 0 | 0 | 20 | 6 | 9 | 4.40 |
| SP | D'Amico, J.D'Amico, Jeff >> | 17 | 2000 | R | 74 | 32 | 32 | 9 | 16 | 4.17 | .292 | 1.23 | 8.3 | 2.8 | 6.3 | 215.2 | 199 | 100 | 100 | 26 | 66 | 150 | 9 | 0 | 0 | 3 | 18 | 2 | 3 | 4.13 |
| SP | Odorizzi, J.Odorizzi, Jake >> | 17 | 2016 | R | 68 | 33 | 32 | 10 | 13 | 5.04 | .311 | 1.34 | 9.1 | 3.0 | 5.3 | 173.1 | 175 | 99 | 97 | 27 | 58 | 101 | 0 | 0 | 0 | 0 | 14 | 2 | 2 | 4.90 |
| SP | Hernandez, L.Hernandez, Livan >> | 17 | 2003 | R | 55 | 34 | 32 | 11 | 11 | 4.78 | .322 | 1.39 | 9.4 | 3.1 | 5.3 | 201.2 | 211 | 111 | 107 | 19 | 69 | 119 | 3 | 0 | 0 | 2 | 14 | 7 | 7 | 4.18 |
| RP | Salas, F.Salas, Fernando >> | 17 | 2011 | R | 96 | 97 | 0 | 3 | 1 | 3.87 | .291 | 1.22 | 7.7 | 3.4 | 8.2 | 88.1 | 75 | 38 | 38 | 11 | 33 | 80 | 0 | 4 | 0 | 0 | 0 | 1 | 2 | 3.97 |
| RP | Diekman, J.Diekman, Jake >> | 17 | 2016 | L | 81 | 103 | 0 | 7 | 0 | 3.75 | .286 | 1.18 | 6.6 | 4.0 | 8.8 | 84.0 | 62 | 36 | 35 | 9 | 37 | 82 | 0 | 9 | 2 | 0 | 0 | 2 | 4 | 3.83 |
| RP | Brantley, J.Brantley, Jeff >> | 17 | 1996 | R | 74 | 80 | 0 | 1 | 2 | 4.23 | .328 | 1.45 | 7.8 | 5.4 | 7.6 | 72.1 | 62 | 41 | 34 | 6 | 43 | 61 | 0 | 6 | 4 | 0 | 0 | 1 | 1 | 4.22 |
| RP | Valverde, J.Valverde, Jose >> | 17 | 2008 | R | 57 | 60 | 0 | 11 | 2 | 3.95 | .282 | 1.15 | 7.5 | 3.0 | 7.7 | 79.2 | 66 | 35 | 35 | 13 | 26 | 68 | 0 | 4 | 2 | 0 | 0 | 2 | 3 | 4.48 |
| RP | Embree, A.Embree, Alan >> | 17 | 2003 | L | 48 | 77 | 0 | 3 | 7 | 4.75 | .357 | 1.63 | 9.9 | 4.8 | 5.8 | 72.0 | 79 | 38 | 38 | 10 | 38 | 46 | 0 | 4 | 3 | 0 | 0 | 3 | 0 | 5.24 |