| SP | Greinke, Z.Greinke, Zack # >> | 32 | 2015 | R | 94 | 35 | 35 | 10 | 14 | 4.17 | .302 | 1.27 | 8.7 | 2.8 | 7.2 | 241.2 | 232 | 115 | 112 | 27 | 76 | 193 | 6 | 0 | 0 | 3 | 16 | 5 | 7 | 3.86 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 34 | 34 | 11 | 9 | 3.80 | .289 | 1.19 | 8.0 | 2.7 | 5.4 | 194.0 | 173 | 88 | 82 | 33 | 58 | 116 | 0 | 0 | 0 | 0 | 15 | 5 | 5 | 4.99 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 33 | 33 | 11 | 10 | 3.84 | .299 | 1.26 | 6.9 | 4.6 | 9.2 | 201.2 | 153 | 90 | 86 | 21 | 102 | 205 | 0 | 0 | 0 | 0 | 24 | 3 | 1 | 3.89 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 32 | 32 | 6 | 14 | 6.23 | .341 | 1.53 | 11.1 | 2.6 | 9.5 | 198.0 | 245 | 148 | 137 | 47 | 57 | 208 | 4 | 0 | 0 | 0 | 8 | 6 | 3 | 4.94 |
| SP | Wilson, D.Wilson, Don # >> | 26 | 1971 | R | 59 | 31 | 31 | 14 | 12 | 4.69 | .313 | 1.35 | 8.7 | 3.4 | 6.3 | 213.0 | 206 | 120 | 111 | 36 | 81 | 148 | 1 | 0 | 0 | 0 | 16 | 4 | 7 | 5.00 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 94 | 86 | 0 | 6 | 4 | 4.59 | .319 | 1.39 | 7.0 | 5.6 | 9.4 | 111.2 | 86 | 59 | 57 | 12 | 69 | 116 | 0 | 4 | 6 | 0 | 0 | 2 | 10 | 4.23 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 66 | 83 | 0 | 9 | 6 | 4.59 | .332 | 1.45 | 7.4 | 5.6 | 9.7 | 102.0 | 84 | 53 | 52 | 18 | 64 | 110 | 0 | 5 | 6 | 0 | 0 | 4 | 5 | 5.14 |
| RP | Williamson, S.Williamson, Scott >> | 23 | 1999 | R | 40 | 45 | 0 | 3 | 1 | 4.15 | .316 | 1.37 | 7.2 | 5.1 | 9.8 | 56.1 | 45 | 27 | 26 | 6 | 32 | 61 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 3.98 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 37 | 2 | 1 | 0 | 1 | 6.43 | .432 | 2.00 | 14.1 | 3.9 | 9.0 | 7.0 | 11 | 5 | 5 | 1 | 3 | 7 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.00 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 21 | 0 | 1 | 4 | 8.23 | .369 | 1.76 | 12.7 | 3.3 | 7.7 | 27.1 | 38 | 25 | 25 | 6 | 10 | 23 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 5.30 |