| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 12 | 12 | 5 | 4 | 1.94 | .247 | 0.98 | 6.1 | 2.8 | 11.0 | 83.1 | 56 | 19 | 18 | 7 | 26 | 101 | 0 | 0 | 0 | 0 | 12 | 0 | 0 | 2.60 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 12 | 12 | 5 | 4 | 4.61 | .292 | 1.19 | 7.6 | 3.1 | 8.7 | 84.0 | 71 | 43 | 43 | 14 | 29 | 81 | 0 | 0 | 0 | 0 | 6 | 4 | 3 | 4.42 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 83 | 11 | 11 | 5 | 4 | 5.01 | .338 | 1.50 | 9.0 | 4.5 | 9.9 | 70.0 | 70 | 39 | 39 | 8 | 35 | 77 | 1 | 0 | 0 | 0 | 4 | 2 | 0 | 3.87 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 63 | 11 | 11 | 3 | 3 | 4.38 | .307 | 1.33 | 9.3 | 2.8 | 7.1 | 61.2 | 63 | 33 | 30 | 14 | 19 | 48 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 5.34 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 21 | 0 | 0 | 2 | 1.27 | .273 | 1.13 | 3.4 | 6.9 | 10.7 | 21.1 | 8 | 4 | 3 | 1 | 16 | 25 | 0 | 13 | 1 | 0 | 0 | 0 | 3 | 3.52 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 68 | 13 | 0 | 1 | 1 | 6.55 | .365 | 1.73 | 11.5 | 4.1 | 6.5 | 11.0 | 14 | 9 | 8 | 3 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.45 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 64 | 14 | 0 | 0 | 1 | 2.03 | .231 | 0.90 | 4.8 | 3.5 | 10.4 | 13.1 | 7 | 3 | 3 | 2 | 5 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.85 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 69 | 5 | 0 | 0 | 2 | 5.18 | .348 | 1.56 | 9.8 | 4.5 | 7.5 | 24.1 | 26 | 14 | 14 | 3 | 12 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.58 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 72 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |