| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 37 | 37 | 16 | 9 | 3.53 | .259 | 1.02 | 6.9 | 2.3 | 11.0 | 239.1 | 182 | 99 | 94 | 37 | 62 | 291 | 2 | 0 | 0 | 1 | 25 | 7 | 0 | 3.44 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 95 | 36 | 36 | 18 | 14 | 4.11 | .299 | 1.24 | 8.8 | 2.4 | 9.0 | 241.0 | 236 | 110 | 110 | 31 | 63 | 242 | 3 | 0 | 0 | 0 | 20 | 9 | 7 | 3.56 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 34 | 34 | 12 | 16 | 4.78 | .316 | 1.36 | 9.0 | 3.2 | 7.7 | 211.0 | 212 | 112 | 112 | 32 | 75 | 181 | 2 | 0 | 0 | 0 | 17 | 5 | 11 | 4.39 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 74 | 31 | 31 | 8 | 7 | 3.88 | .310 | 1.33 | 8.3 | 3.7 | 8.1 | 146.0 | 134 | 63 | 63 | 16 | 60 | 132 | 0 | 0 | 0 | 0 | 1 | 3 | 4 | 3.91 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 64 | 0 | 4 | 5 | 2.84 | .272 | 1.09 | 6.6 | 3.3 | 11.7 | 63.1 | 46 | 22 | 20 | 7 | 23 | 82 | 0 | 47 | 3 | 0 | 0 | 2 | 2 | 3.03 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 55 | 0 | 1 | 3 | 4.58 | .316 | 1.37 | 8.1 | 4.3 | 7.9 | 57.0 | 51 | 31 | 29 | 7 | 27 | 50 | 0 | 6 | 8 | 0 | 0 | 1 | 0 | 4.32 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 77 | 0 | 4 | 2 | 5.12 | .305 | 1.28 | 8.6 | 3.0 | 9.0 | 84.1 | 80 | 50 | 48 | 14 | 28 | 84 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 4.27 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 54 | 0 | 7 | 2 | 3.00 | .274 | 1.10 | 8.6 | 1.4 | 8.3 | 60.0 | 57 | 20 | 20 | 10 | 9 | 55 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.88 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 65 | 16 | 0 | 1 | 1 | 6.28 | .377 | 1.74 | 10.3 | 5.8 | 6.4 | 14.1 | 16 | 10 | 10 | 2 | 9 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.57 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 63 | 24 | 0 | 1 | 1 | 1.90 | .245 | 0.93 | 6.7 | 2.0 | 9.4 | 23.2 | 17 | 5 | 5 | 1 | 5 | 24 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2.26 |