| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 89 | 33 | 33 | 13 | 14 | 4.54 | .318 | 1.38 | 9.9 | 2.5 | 8.4 | 214.0 | 235 | 116 | 108 | 22 | 60 | 199 | 1 | 0 | 0 | 0 | 18 | 4 | 4 | 3.37 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 93 | 34 | 34 | 8 | 13 | 4.04 | .325 | 1.44 | 8.4 | 4.6 | 9.2 | 211.2 | 198 | 104 | 95 | 21 | 107 | 215 | 0 | 0 | 0 | 0 | 24 | 1 | 3 | 3.79 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 78 | 31 | 30 | 13 | 9 | 5.57 | .364 | 1.70 | 11.9 | 3.4 | 8.6 | 179.1 | 236 | 116 | 111 | 27 | 68 | 171 | 0 | 0 | 0 | 0 | 8 | 4 | 4 | 4.26 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 79 | 81 | 0 | 7 | 5 | 4.29 | .309 | 1.30 | 8.7 | 3.1 | 8.3 | 100.2 | 97 | 53 | 48 | 12 | 34 | 92 | 0 | 0 | 5 | 0 | 0 | 4 | 6 | 3.86 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 58 | 0 | 2 | 2 | 4.17 | .314 | 1.35 | 9.8 | 2.5 | 10.4 | 58.1 | 63 | 28 | 27 | 6 | 16 | 67 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 2.91 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 50 | 0 | 3 | 2 | 2.32 | .317 | 1.39 | 8.1 | 4.5 | 10.6 | 50.1 | 45 | 15 | 13 | 6 | 25 | 59 | 0 | 0 | 2 | 0 | 0 | 0 | 4 | 3.70 |
| RP | Yates, K.Yates, Kirby # >> | 32 | 2019 | R | 57 | 31 | 0 | 0 | 0 | 6.43 | .323 | 1.43 | 9.8 | 3.1 | 11.1 | 35.0 | 38 | 25 | 25 | 7 | 12 | 43 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.17 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 17 | 4 | 3 | 1 | 6.07 | .335 | 1.47 | 10.3 | 3.1 | 6.1 | 72.2 | 82 | 53 | 49 | 17 | 25 | 49 | 0 | 0 | 1 | 0 | 1 | 3 | 1 | 5.88 |
| CL | Hader, J.Hader, Josh † # >> | 24 | 2018 | L | 92 | 64 | 0 | 8 | 9 | 3.97 | .306 | 1.28 | 7.6 | 4.0 | 9.6 | 65.2 | 55 | 29 | 29 | 6 | 29 | 69 | 0 | 37 | 7 | 0 | 0 | 3 | 0 | 3.55 |