| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 90 | 12 | 12 | 2 | 7 | 6.03 | .321 | 1.35 | 9.7 | 2.6 | 7.5 | 77.2 | 83 | 53 | 52 | 12 | 22 | 64 | 3 | 0 | 0 | 0 | 3 | 5 | 4 | 4.42 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 90 | 12 | 12 | 5 | 4 | 4.06 | .260 | 1.03 | 7.3 | 2.0 | 9.4 | 84.1 | 68 | 40 | 38 | 10 | 19 | 88 | 1 | 0 | 0 | 1 | 6 | 2 | 0 | 3.20 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 28 | 0 | 2 | 2 | 2.43 | .288 | 1.18 | 6.8 | 4.0 | 11.2 | 29.2 | 22 | 8 | 8 | 5 | 13 | 36 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.21 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 14 | 0 | 3 | 0 | 0.54 | .138 | 0.48 | 3.4 | 1.1 | 13.5 | 16.2 | 6 | 1 | 1 | 1 | 2 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.19 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 11 | 0 | 0 | 0 | 2.61 | .262 | 1.06 | 8.1 | 1.8 | 7.2 | 10.1 | 9 | 3 | 3 | 1 | 2 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.30 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 6 | 0 | 0 | 0 | 7.20 | .348 | 1.40 | 10.8 | 1.8 | 5.4 | 5.0 | 6 | 4 | 4 | 3 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 10.80 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 6 | 1 | 0 | 1 | 7.33 | .375 | 1.80 | 12.5 | 3.9 | 9.4 | 23.1 | 32 | 20 | 19 | 7 | 10 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.17 |