| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 27 | 27 | 9 | 9 | 3.93 | .309 | 1.30 | 7.0 | 4.8 | 9.9 | 171.2 | 133 | 79 | 75 | 12 | 91 | 188 | 0 | 0 | 0 | 0 | 17 | 6 | 4 | 3.42 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 90 | 27 | 27 | 14 | 9 | 4.10 | .297 | 1.25 | 8.8 | 2.5 | 7.2 | 195.1 | 190 | 92 | 89 | 21 | 55 | 156 | 4 | 0 | 0 | 0 | 13 | 3 | 3 | 3.69 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 26 | 26 | 7 | 12 | 5.96 | .347 | 1.57 | 10.0 | 4.1 | 9.1 | 157.0 | 175 | 111 | 104 | 32 | 72 | 159 | 2 | 0 | 0 | 0 | 9 | 3 | 6 | 5.06 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 71 | 26 | 26 | 7 | 12 | 5.36 | .354 | 1.61 | 11.0 | 3.6 | 7.1 | 152.2 | 186 | 104 | 91 | 28 | 60 | 120 | 1 | 0 | 0 | 0 | 7 | 5 | 8 | 5.10 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 96 | 47 | 0 | 3 | 5 | 2.61 | .275 | 1.14 | 7.7 | 2.6 | 10.1 | 48.1 | 41 | 14 | 14 | 5 | 14 | 54 | 0 | 25 | 1 | 0 | 0 | 0 | 0 | 2.98 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 40 | 0 | 4 | 1 | 3.65 | .318 | 1.38 | 8.8 | 3.7 | 10.8 | 44.1 | 43 | 19 | 18 | 3 | 18 | 53 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.77 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 33 | 0 | 3 | 1 | 1.93 | .273 | 1.07 | 5.6 | 4.1 | 10.2 | 37.1 | 23 | 9 | 8 | 4 | 17 | 42 | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 3.68 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 8 | 0 | 2 | 2 | 2.35 | .343 | 1.57 | 10.3 | 5.1 | 10.3 | 7.2 | 8 | 2 | 2 | 0 | 4 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.43 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 21 | 0 | 1 | 0 | 2.93 | .265 | 1.01 | 6.0 | 3.3 | 10.0 | 27.2 | 18 | 9 | 9 | 5 | 10 | 30 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 4.52 |