| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 28 | 28 | 18 | 7 | 2.74 | .257 | 0.99 | 6.7 | 2.2 | 10.4 | 190.1 | 141 | 64 | 58 | 18 | 47 | 220 | 1 | 0 | 0 | 1 | 23 | 10 | 0 | 2.82 |
| SP | Scott, M.Scott, Mike † >> | 31 | 1986 | R | 92 | 27 | 27 | 13 | 9 | 3.53 | .295 | 1.22 | 7.7 | 3.3 | 9.3 | 196.1 | 167 | 80 | 77 | 27 | 72 | 202 | 7 | 0 | 0 | 2 | 18 | 7 | 6 | 3.94 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 84 | 26 | 26 | 14 | 8 | 2.99 | .278 | 1.14 | 8.0 | 2.3 | 5.9 | 192.2 | 171 | 82 | 64 | 22 | 49 | 126 | 7 | 0 | 0 | 3 | 18 | 3 | 1 | 3.99 |
| SP | Flaherty, J.Flaherty, Jack >> | 23 | 2019 | R | 83 | 26 | 26 | 7 | 9 | 3.87 | .292 | 1.23 | 7.8 | 3.3 | 8.7 | 160.2 | 139 | 73 | 69 | 24 | 59 | 155 | 0 | 0 | 0 | 0 | 12 | 1 | 5 | 4.14 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 72 | 24 | 24 | 9 | 9 | 5.45 | .348 | 1.55 | 11.3 | 2.7 | 5.9 | 135.1 | 169 | 86 | 82 | 18 | 41 | 88 | 0 | 0 | 0 | 0 | 10 | 7 | 0 | 4.50 |
| RP | Green, C.Green, Chad † >> | 26 | 2017 | R | 95 | 68 | 0 | 6 | 5 | 2.88 | .263 | 1.04 | 5.9 | 3.5 | 10.4 | 112.1 | 73 | 42 | 36 | 12 | 44 | 130 | 0 | 9 | 3 | 0 | 0 | 3 | 2 | 3.33 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 87 | 53 | 0 | 4 | 0 | 2.14 | .249 | 1.00 | 5.8 | 3.2 | 10.3 | 67.1 | 43 | 17 | 16 | 7 | 24 | 77 | 0 | 12 | 2 | 0 | 0 | 0 | 3 | 3.13 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 83 | 29 | 0 | 0 | 2 | 4.45 | .300 | 1.25 | 7.2 | 4.2 | 12.3 | 30.1 | 24 | 15 | 15 | 4 | 14 | 41 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 3.50 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 20 | 0 | 3 | 1 | 6.30 | .375 | 1.75 | 10.8 | 5.0 | 10.4 | 20.0 | 24 | 14 | 14 | 6 | 11 | 23 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 6.40 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 17 | 0 | 0 | 5 | 7.53 | .419 | 2.09 | 12.2 | 7.1 | 12.9 | 14.1 | 19 | 14 | 12 | 5 | 11 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 7.36 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 65 | 18 | 0 | 2 | 1 | 3.60 | .326 | 1.35 | 6.8 | 5.4 | 7.2 | 20.0 | 15 | 10 | 8 | 3 | 12 | 16 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 5.45 |