| SP | Matsuzaka, D.Matsuzaka, Daisuke + >> | 27 | 2007 | R | 81 | 32 | 32 | 8 | 15 | 4.86 | .332 | 1.46 | 9.6 | 3.5 | 6.9 | 226.0 | 241 | 124 | 122 | 31 | 89 | 174 | 5 | 0 | 0 | 2 | 13 | 7 | 3 | 4.52 |
| SP | Glavine, T.Glavine, Tom # >> | 41 | 2007 | L | 51 | 34 | 34 | 14 | 12 | 4.01 | .317 | 1.35 | 9.1 | 3.1 | 6.0 | 244.2 | 248 | 113 | 109 | 30 | 83 | 164 | 3 | 0 | 0 | 0 | 20 | 10 | 1 | 4.40 |
| SP | Mussina, M.Mussina, Mike >> | 39 | 2007 | R | 37 | 32 | 32 | 10 | 13 | 4.74 | .336 | 1.47 | 10.6 | 2.7 | 5.9 | 199.1 | 234 | 106 | 105 | 27 | 59 | 131 | 2 | 0 | 0 | 0 | 16 | 10 | 2 | 4.49 |
| SP | Morris, M.Morris, Matt >> | 33 | 2007 | R | 33 | 26 | 26 | 14 | 6 | 3.76 | .315 | 1.35 | 8.8 | 3.3 | 5.2 | 189.1 | 185 | 80 | 79 | 19 | 70 | 110 | 5 | 0 | 0 | 2 | 14 | 6 | 4 | 4.35 |
| RP | Sherrill, G.Sherrill, George >> | 30 | 2007 | L | 99 | 102 | 0 | 7 | 2 | 1.94 | .275 | 1.07 | 6.1 | 3.6 | 11.4 | 83.1 | 56 | 19 | 18 | 8 | 33 | 105 | 0 | 7 | 4 | 0 | 0 | 6 | 1 | 3.13 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 99 | 92 | 0 | 8 | 5 | 2.72 | .259 | 1.00 | 7.0 | 2.0 | 9.5 | 109.0 | 85 | 33 | 33 | 12 | 24 | 115 | 0 | 11 | 3 | 0 | 0 | 5 | 0 | 3.12 |
| RP | Turnbow, D.Turnbow, Derrick >> | 29 | 2007 | R | 84 | 61 | 0 | 4 | 7 | 3.28 | .273 | 1.09 | 6.6 | 3.3 | 9.6 | 60.1 | 44 | 22 | 22 | 2 | 22 | 64 | 0 | 8 | 2 | 0 | 0 | 2 | 6 | 2.50 |
| RP | Donnelly, B.Donnelly, Brendan >> | 36 | 2007 | R | 76 | 23 | 0 | 2 | 0 | 3.62 | .287 | 1.17 | 9.3 | 1.3 | 8.0 | 27.1 | 28 | 11 | 11 | 4 | 4 | 24 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.70 |
| SP | Suppan, J.Suppan, Jeff >> | 32 | 2007 | R | 37 | 12 | 4 | 2 | 1 | 5.88 | .369 | 1.63 | 12.5 | 2.5 | 6.3 | 33.2 | 46 | 22 | 22 | 4 | 9 | 23 | 0 | 3 | 0 | 0 | 0 | 4 | 1 | 4.36 |