| SP | Lackey, J.Lackey, John + >> | 29 | 2007 | R | 86 | 36 | 36 | 16 | 14 | 3.88 | .291 | 1.20 | 8.0 | 2.8 | 7.1 | 248.0 | 220 | 117 | 107 | 29 | 77 | 196 | 6 | 0 | 0 | 4 | 21 | 9 | 2 | 3.98 |
| SP | Buehrle, M.Buehrle, Mark >> | 28 | 2007 | L | 75 | 35 | 35 | 17 | 11 | 3.58 | .295 | 1.22 | 8.6 | 2.5 | 6.0 | 246.2 | 234 | 109 | 98 | 18 | 67 | 163 | 2 | 0 | 0 | 1 | 20 | 8 | 4 | 3.54 |
| SP | Wakefield, T.Wakefield, Tim >> | 41 | 2007 | R | 70 | 34 | 34 | 11 | 11 | 4.37 | .329 | 1.45 | 9.3 | 3.7 | 5.9 | 210.0 | 218 | 108 | 102 | 16 | 87 | 137 | 0 | 0 | 0 | 0 | 20 | 4 | 10 | 3.99 |
| SP | Arroyo, B.Arroyo, Bronson >> | 30 | 2007 | R | 58 | 27 | 25 | 6 | 15 | 4.91 | .316 | 1.34 | 9.4 | 2.7 | 6.0 | 152.0 | 158 | 91 | 83 | 18 | 46 | 101 | 1 | 0 | 0 | 1 | 10 | 7 | 2 | 4.26 |
| RP | Acosta, M.Acosta, Manny >> | 26 | 2007 | R | 93 | 107 | 0 | 3 | 4 | 2.77 | .295 | 1.20 | 5.9 | 5.0 | 7.0 | 110.2 | 72 | 34 | 34 | 5 | 61 | 85 | 0 | 9 | 3 | 0 | 0 | 6 | 4 | 3.87 |
| RP | Timlin, M.Timlin, Mike >> | 41 | 2007 | R | 82 | 90 | 0 | 2 | 4 | 2.72 | .307 | 1.26 | 8.9 | 2.5 | 7.0 | 89.1 | 88 | 30 | 27 | 5 | 25 | 69 | 0 | 14 | 3 | 0 | 0 | 6 | 0 | 3.22 |
| RP | Rivera, M.Rivera, Mariano + >> | 38 | 2007 | R | 82 | 71 | 0 | 7 | 4 | 3.61 | .318 | 1.37 | 9.8 | 2.6 | 8.2 | 67.1 | 73 | 29 | 27 | 4 | 19 | 61 | 0 | 9 | 2 | 0 | 0 | 2 | 2 | 2.90 |
| RP | Casilla, S.Casilla, Santiago >> | 27 | 2007 | R | 79 | 40 | 0 | 3 | 4 | 4.67 | .335 | 1.49 | 9.2 | 4.3 | 8.8 | 44.1 | 45 | 24 | 23 | 3 | 21 | 43 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 3.43 |
| RP | Villone, R.Villone, Ron >> | 37 | 2007 | L | 74 | 123 | 0 | 5 | 5 | 3.47 | .261 | 1.05 | 6.8 | 2.8 | 6.6 | 85.2 | 64 | 37 | 33 | 5 | 26 | 62 | 0 | 4 | 2 | 0 | 0 | 1 | 5 | 3.26 |