| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 18 | 18 | 11 | 5 | 3.04 | .268 | 1.09 | 7.4 | 2.4 | 7.9 | 139.0 | 114 | 53 | 47 | 16 | 37 | 122 | 7 | 0 | 0 | 1 | 14 | 2 | 6 | 3.58 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 17 | 17 | 10 | 5 | 3.08 | .256 | 1.03 | 7.6 | 1.7 | 4.5 | 128.2 | 108 | 45 | 44 | 12 | 24 | 64 | 5 | 0 | 0 | 3 | 10 | 1 | 1 | 3.80 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 17 | 17 | 4 | 10 | 5.45 | .311 | 1.35 | 9.2 | 3.0 | 4.6 | 110.2 | 112 | 68 | 67 | 16 | 37 | 56 | 3 | 0 | 0 | 0 | 7 | 1 | 3 | 4.91 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 17 | 17 | 6 | 7 | 4.28 | .303 | 1.30 | 7.7 | 4.0 | 5.1 | 115.2 | 99 | 63 | 55 | 15 | 51 | 65 | 2 | 0 | 0 | 0 | 11 | 1 | 2 | 4.92 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 17 | 17 | 8 | 6 | 5.25 | .337 | 1.52 | 10.1 | 3.5 | 5.1 | 94.1 | 106 | 58 | 55 | 11 | 37 | 53 | 1 | 0 | 0 | 0 | 10 | 1 | 3 | 4.61 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 45 | 0 | 0 | 4 | 2.77 | .270 | 1.08 | 5.8 | 4.0 | 9.1 | 68.1 | 44 | 22 | 21 | 12 | 30 | 69 | 0 | 8 | 3 | 0 | 0 | 2 | 0 | 4.68 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 33 | 0 | 4 | 1 | 3.00 | .284 | 1.14 | 8.4 | 1.9 | 5.6 | 42.0 | 39 | 14 | 14 | 4 | 9 | 26 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 3.79 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 21 | 0 | 2 | 0 | 1.23 | .313 | 1.36 | 9.0 | 3.3 | 11.0 | 22.0 | 22 | 3 | 3 | 0 | 8 | 27 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 1.64 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 16 | 0 | 1 | 0 | 4.00 | .229 | 0.89 | 6.0 | 2.0 | 9.5 | 18.0 | 12 | 8 | 8 | 4 | 4 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.44 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 52 | 3 | 0 | 0 | 0 | 2.70 | .231 | 0.90 | 7.5 | 1.5 | 4.5 | 6.2 | 5 | 2 | 2 | 0 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.50 |