| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 29 | 29 | 13 | 8 | 3.21 | .302 | 1.28 | 7.9 | 3.6 | 6.9 | 210.0 | 185 | 81 | 75 | 17 | 83 | 161 | 5 | 0 | 0 | 2 | 19 | 5 | 6 | 3.78 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 28 | 28 | 7 | 8 | 4.73 | .324 | 1.43 | 10.0 | 3.0 | 4.3 | 167.1 | 185 | 98 | 88 | 17 | 55 | 80 | 3 | 0 | 0 | 0 | 14 | 1 | 4 | 4.37 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 27 | 27 | 7 | 8 | 5.80 | .365 | 1.72 | 9.1 | 6.4 | 8.1 | 127.1 | 128 | 85 | 82 | 19 | 91 | 114 | 0 | 0 | 0 | 0 | 9 | 1 | 0 | 5.32 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 28 | 27 | 14 | 11 | 4.85 | .313 | 1.36 | 8.9 | 3.3 | 4.8 | 174.1 | 173 | 101 | 94 | 23 | 64 | 93 | 1 | 0 | 0 | 0 | 13 | 1 | 4 | 4.77 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 73 | 0 | 6 | 0 | 4.01 | .343 | 1.54 | 9.9 | 4.0 | 8.1 | 74.0 | 81 | 37 | 33 | 9 | 33 | 67 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 4.19 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 66 | 0 | 6 | 4 | 4.14 | .302 | 1.26 | 7.6 | 3.8 | 5.7 | 71.2 | 60 | 37 | 33 | 9 | 30 | 45 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 4.77 |
| RP | Holland, G.Holland, Greg $ >> | 27 | 2013 | R | 72 | 46 | 0 | 2 | 3 | 4.79 | .332 | 1.47 | 9.5 | 3.9 | 9.0 | 56.1 | 59 | 31 | 30 | 3 | 24 | 56 | 0 | 0 | 2 | 0 | 0 | 1 | 3 | 3.04 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 39 | 0 | 3 | 2 | 4.60 | .310 | 1.35 | 9.0 | 3.1 | 10.3 | 43.0 | 43 | 22 | 22 | 5 | 15 | 49 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.28 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 50 | 0 | 2 | 4 | 6.97 | .343 | 1.53 | 8.5 | 5.4 | 7.9 | 50.1 | 47 | 40 | 39 | 8 | 30 | 44 | 0 | 2 | 8 | 0 | 0 | 2 | 0 | 5.24 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 34 | 0 | 1 | 0 | 3.63 | .292 | 1.21 | 9.2 | 1.8 | 8.1 | 39.2 | 40 | 18 | 16 | 4 | 8 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.23 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 55 | 0 | 2 | 7 | 4.10 | .301 | 1.27 | 8.0 | 3.6 | 11.1 | 52.2 | 46 | 25 | 24 | 6 | 21 | 64 | 0 | 27 | 6 | 0 | 0 | 1 | 1 | 3.31 |