| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 93 | 35 | 35 | 13 | 15 | 3.81 | .284 | 1.17 | 8.0 | 2.5 | 7.1 | 264.1 | 236 | 115 | 112 | 24 | 73 | 209 | 7 | 0 | 0 | 2 | 17 | 5 | 3 | 3.48 |
| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 33 | 33 | 15 | 8 | 3.99 | .286 | 1.20 | 7.4 | 3.4 | 5.8 | 219.0 | 181 | 99 | 97 | 24 | 82 | 140 | 2 | 0 | 0 | 2 | 19 | 0 | 1 | 4.27 |
| SP | Maddux, G.Maddux, Greg † $ >> | 29 | 1995 | R | 89 | 32 | 32 | 18 | 10 | 4.15 | .301 | 1.27 | 9.2 | 2.3 | 6.1 | 236.1 | 240 | 119 | 109 | 21 | 60 | 161 | 9 | 0 | 0 | 1 | 15 | 5 | 5 | 3.62 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 31 | 31 | 14 | 9 | 3.80 | .299 | 1.26 | 8.7 | 2.7 | 4.4 | 227.2 | 219 | 110 | 96 | 26 | 67 | 110 | 8 | 0 | 0 | 2 | 18 | 6 | 4 | 4.48 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 74 | 0 | 5 | 2 | 3.33 | .274 | 1.10 | 7.1 | 2.8 | 8.1 | 97.1 | 77 | 37 | 36 | 14 | 30 | 87 | 0 | 5 | 6 | 0 | 0 | 3 | 2 | 4.10 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 91 | 63 | 0 | 5 | 6 | 4.25 | .263 | 1.06 | 7.3 | 2.3 | 9.6 | 72.0 | 58 | 34 | 34 | 13 | 18 | 77 | 0 | 15 | 1 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 39 | 0 | 5 | 4 | 1.58 | .226 | 0.85 | 5.2 | 2.5 | 8.1 | 40.0 | 23 | 7 | 7 | 3 | 11 | 36 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 3.08 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 21 | 0 | 2 | 1 | 2.14 | .284 | 1.19 | 7.3 | 3.4 | 8.6 | 21.0 | 17 | 8 | 5 | 2 | 8 | 20 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.48 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 21 | 0 | 3 | 1 | 1.04 | .257 | 1.04 | 6.2 | 3.1 | 5.9 | 26.0 | 18 | 4 | 3 | 1 | 9 | 17 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.23 |