| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 28 | 28 | 15 | 4 | 2.12 | .249 | 0.97 | 5.9 | 2.8 | 4.1 | 203.1 | 133 | 52 | 48 | 8 | 64 | 93 | 1 | 0 | 0 | 1 | 22 | 5 | 1 | 3.62 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 28 | 28 | 15 | 11 | 2.90 | .247 | 0.96 | 7.0 | 1.7 | 5.0 | 223.1 | 173 | 75 | 72 | 19 | 41 | 124 | 18 | 0 | 0 | 4 | 19 | 6 | 2 | 3.63 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 25 | 0 | 2 | 2 | 4.34 | .298 | 1.28 | 8.4 | 3.1 | 5.9 | 29.0 | 27 | 14 | 14 | 6 | 10 | 19 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 5.41 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 14 | 0 | 1 | 1 | 4.85 | .350 | 1.62 | 7.6 | 6.9 | 6.9 | 13.0 | 11 | 9 | 7 | 2 | 10 | 10 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.77 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 7 | 0 | 0 | 0 | 2.89 | .300 | 1.29 | 8.0 | 4.0 | 9.0 | 9.1 | 8 | 3 | 3 | 1 | 4 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.78 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 26 | 26 | 10 | 12 | 4.18 | .304 | 1.28 | 8.2 | 3.4 | 4.4 | 194.0 | 176 | 93 | 90 | 18 | 73 | 95 | 8 | 0 | 0 | 0 | 14 | 5 | 0 | 4.43 |
| SP | Tanana, F.Tanana, Frank $ >> | 23 | 1976 | L | 57 | 2 | 1 | 1 | 1 | 3.18 | .277 | 1.15 | 7.4 | 3.3 | 6.5 | 11.1 | 9 | 4 | 4 | 2 | 4 | 8 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 5.00 |
| RP | Williamson, S.Williamson, Scott >> | 23 | 1999 | R | 45 | 18 | 0 | 0 | 1 | 0.93 | .266 | 1.09 | 6.6 | 3.3 | 6.6 | 19.1 | 14 | 2 | 2 | 1 | 7 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.32 |