| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 12 | 7 | 2.53 | .268 | 1.09 | 7.3 | 2.5 | 9.9 | 163.2 | 133 | 47 | 46 | 12 | 46 | 179 | 0 | 0 | 0 | 0 | 19 | 1 | 0 | 2.63 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 24 | 24 | 9 | 4 | 3.47 | .286 | 1.17 | 8.4 | 2.2 | 5.7 | 173.2 | 161 | 78 | 67 | 16 | 43 | 109 | 5 | 0 | 0 | 0 | 17 | 5 | 5 | 3.77 |
| SP | Carlton, S.Carlton, Steve † >> | 28 | 1972 | L | 51 | 22 | 22 | 13 | 6 | 3.09 | .289 | 1.20 | 8.3 | 2.6 | 5.3 | 168.2 | 155 | 64 | 58 | 14 | 48 | 99 | 7 | 0 | 0 | 2 | 15 | 3 | 4 | 3.82 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 41 | 0 | 3 | 2 | 4.91 | .309 | 1.30 | 8.0 | 3.7 | 7.0 | 44.0 | 39 | 25 | 24 | 6 | 18 | 34 | 0 | 2 | 6 | 0 | 0 | 2 | 0 | 4.59 |
| RP | Capps, C.Capps, Carter † >> | 24 | 2015 | R | 84 | 61 | 0 | 7 | 1 | 2.55 | .244 | 0.93 | 5.9 | 2.4 | 9.8 | 67.0 | 44 | 19 | 19 | 3 | 18 | 73 | 0 | 4 | 0 | 0 | 0 | 3 | 2 | 2.34 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 35 | 0 | 1 | 4 | 3.38 | .313 | 1.34 | 7.3 | 4.9 | 10.0 | 37.1 | 30 | 14 | 14 | 2 | 20 | 41 | 0 | 3 | 0 | 0 | 0 | 1 | 6 | 3.19 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 25 | 0 | 3 | 1 | 2.25 | .294 | 1.25 | 7.1 | 4.1 | 6.0 | 24.0 | 19 | 9 | 6 | 2 | 11 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.13 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 13 | 0 | 2 | 2 | 3.86 | .255 | 1.03 | 8.2 | 1.6 | 8.2 | 11.2 | 10 | 6 | 5 | 1 | 2 | 10 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.91 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 6 | 0 | 1 | 0 | 4.20 | .357 | 1.63 | 9.3 | 5.4 | 8.7 | 30.0 | 31 | 16 | 14 | 2 | 18 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.83 |