| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 8 | 8 | 3 | 2 | 5.17 | .302 | 1.30 | 7.1 | 4.6 | 4.4 | 47.0 | 37 | 28 | 27 | 7 | 24 | 23 | 1 | 0 | 0 | 0 | 5 | 0 | 1 | 5.49 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 8 | 8 | 3 | 4 | 5.09 | .349 | 1.54 | 9.6 | 4.3 | 4.1 | 46.0 | 49 | 27 | 26 | 4 | 22 | 21 | 1 | 0 | 0 | 0 | 4 | 3 | 1 | 4.85 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 21 | 0 | 0 | 1 | 6.64 | .344 | 1.57 | 8.6 | 5.9 | 9.9 | 20.1 | 19 | 16 | 15 | 5 | 13 | 22 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 6.00 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 22 | 0 | 1 | 0 | 5.64 | .337 | 1.52 | 10.2 | 3.7 | 6.5 | 22.1 | 25 | 14 | 14 | 3 | 9 | 16 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.55 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 20 | 0 | 1 | 0 | 3.86 | .333 | 1.50 | 10.3 | 3.2 | 3.9 | 14.0 | 16 | 8 | 6 | 4 | 5 | 6 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 6.93 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 12 | 0 | 2 | 2 | 3.60 | .268 | 1.10 | 5.4 | 4.5 | 10.8 | 10.0 | 6 | 4 | 4 | 1 | 5 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.40 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 9 | 0 | 0 | 0 | 2.77 | .250 | 1.00 | 5.5 | 3.5 | 9.7 | 13.0 | 8 | 4 | 4 | 0 | 5 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |