| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 33 | 33 | 18 | 10 | 4.42 | .298 | 1.26 | 7.3 | 4.1 | 4.4 | 201.2 | 163 | 101 | 99 | 26 | 91 | 98 | 4 | 0 | 0 | 0 | 19 | 3 | 5 | 5.11 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 98 | 0 | 7 | 3 | 3.66 | .298 | 1.25 | 7.0 | 4.4 | 9.9 | 93.1 | 72 | 44 | 38 | 12 | 45 | 102 | 0 | 4 | 4 | 0 | 0 | 2 | 3 | 4.00 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 97 | 0 | 3 | 3 | 3.10 | .272 | 1.10 | 6.9 | 3.0 | 7.8 | 95.2 | 73 | 34 | 33 | 9 | 32 | 82 | 0 | 6 | 2 | 0 | 0 | 2 | 0 | 3.58 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 87 | 0 | 3 | 1 | 4.01 | .323 | 1.42 | 9.3 | 3.6 | 7.5 | 60.2 | 62 | 29 | 27 | 9 | 24 | 50 | 0 | 8 | 1 | 0 | 0 | 1 | 8 | 4.53 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 52 | 0 | 4 | 6 | 4.53 | .315 | 1.36 | 9.0 | 3.4 | 7.0 | 45.2 | 45 | 23 | 23 | 7 | 17 | 35 | 0 | 7 | 0 | 0 | 0 | 1 | 0 | 4.67 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 31 | 0 | 3 | 1 | 3.23 | .269 | 1.08 | 5.1 | 4.6 | 9.7 | 39.0 | 22 | 14 | 14 | 4 | 20 | 42 | 0 | 5 | 0 | 0 | 0 | 1 | 2 | 3.79 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 31 | 31 | 10 | 14 | 4.64 | .312 | 1.33 | 8.2 | 3.8 | 4.0 | 197.2 | 179 | 111 | 102 | 20 | 83 | 88 | 6 | 0 | 0 | 1 | 14 | 7 | 2 | 4.80 |