| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 18 | 18 | 7 | 7 | 3.45 | .295 | 1.25 | 8.3 | 3.0 | 8.0 | 127.2 | 117 | 59 | 49 | 18 | 42 | 113 | 0 | 0 | 0 | 0 | 10 | 1 | 1 | 4.08 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 17 | 17 | 6 | 8 | 3.64 | .305 | 1.31 | 9.2 | 2.6 | 6.7 | 123.2 | 126 | 51 | 50 | 16 | 36 | 92 | 2 | 0 | 0 | 0 | 11 | 1 | 5 | 4.10 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 18 | 17 | 12 | 5 | 3.11 | .278 | 1.12 | 8.0 | 2.1 | 4.9 | 133.0 | 118 | 51 | 46 | 5 | 31 | 72 | 6 | 0 | 0 | 4 | 9 | 5 | 1 | 3.22 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 15 | 15 | 5 | 7 | 5.78 | .350 | 1.60 | 10.0 | 4.5 | 4.6 | 99.2 | 110 | 75 | 64 | 10 | 49 | 51 | 1 | 0 | 0 | 0 | 5 | 2 | 5 | 4.83 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 49 | 0 | 0 | 3 | 3.74 | .284 | 1.13 | 8.2 | 2.2 | 6.5 | 33.2 | 30 | 14 | 14 | 1 | 8 | 24 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 2.85 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 36 | 0 | 2 | 4 | 6.39 | .340 | 1.55 | 9.6 | 4.4 | 9.3 | 31.0 | 33 | 22 | 22 | 9 | 15 | 32 | 0 | 10 | 4 | 0 | 0 | 0 | 1 | 6.16 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 20 | 0 | 0 | 1 | 2.61 | .367 | 1.74 | 9.5 | 6.8 | 8.1 | 20.2 | 21 | 7 | 6 | 1 | 15 | 18 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.10 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 13 | 0 | 1 | 0 | 9.24 | .415 | 2.13 | 15.0 | 5.3 | 9.8 | 12.2 | 20 | 13 | 13 | 5 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.00 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 5 | 2 | 1 | 0 | 3.66 | .352 | 1.53 | 9.0 | 5.2 | 3.8 | 19.2 | 19 | 8 | 8 | 1 | 11 | 8 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 4.89 |